Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification.

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作者信息

Ito K, Uchino H

出版信息

J Biol Chem. 1973 Jan 25;248(2):389-92.

PMID:4684686

Abstract

摘要

相似文献

Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification.

J Biol Chem. 1973 Jan 25;248(2):389-92.

Control of pyrimidine biosynthesis in human lymphocytes. Induction of glutamine-utilizing carbamyl phosphate synthetase and operation of orotic acid pathway during blastogenesis.人类淋巴细胞中嘧啶生物合成的调控。有丝分裂原刺激过程中谷氨酰胺利用型氨甲酰磷酸合成酶的诱导及乳清酸途径的运作。

J Biol Chem. 1971 Jun 25;246(12):4060-5.

Control of pyrimidine biosynthesis in human lymphocytes. Inhibitory effect of guanine and guanosine on induction of enzymes for pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes.

J Biol Chem. 1976 Mar 10;251(5):1427-30.

Control of pyrimidine biosynthesis in human lymphocytes. Inhibition of pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes by external uridine and its inhibition mechanism.人淋巴细胞中嘧啶生物合成的调控。外源性尿苷对植物血凝素刺激的淋巴细胞中嘧啶从头生物合成的抑制作用及其抑制机制。

J Biol Chem. 1973 Jul 10;248(13):4782-5.

Immunochemical analysis of the domain structure of CAD, the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells.对CAD结构域的免疫化学分析，CAD是一种在哺乳动物细胞中启动嘧啶生物合成的多功能蛋白质。

J Biol Chem. 1985 Dec 15;260(29):15840-9.

Purification of homogeneous glutamine-dependent carbamyl phosphate synthetase from ascites hepatoma cells as a complex with aspartate transcarbamylase and dihydroorotase.从腹水肝癌细胞中纯化出与天冬氨酸转氨甲酰酶和二氢乳清酸酶形成复合物的纯质谷氨酰胺依赖性氨甲酰磷酸合成酶。

J Biochem. 1975 Jul;78(1):239-42.

Purification of a multifunctional protein bearing carbamyl-phosphate synthase, aspartate transcarbamylase, and dihydroorotase enzyme activities from mutant hamster cells.从突变仓鼠细胞中纯化一种具有氨甲酰磷酸合成酶、天冬氨酸转氨甲酰酶和二氢乳清酸酶活性的多功能蛋白质。

Methods Enzymol. 1978;51:121-34. doi: 10.1016/s0076-6879(78)51020-3.

Copurification of pyrimidine-specific carbamyl phosphate synthetase and aspartate transcarbamylase of Neurospora crassa.粗糙脉孢菌嘧啶特异性氨甲酰磷酸合成酶与天冬氨酸转氨甲酰酶的共纯化

Biochemistry. 1970 Oct 27;9(22):4329-35. doi: 10.1021/bi00824a013.

Control of pyrimidine biosynthesis in mammalian tissues. I. Partial purification and characterization of glutamine-utilizing carbamyl phosphate synthetase of mouse spleen and its tissue distribution.

J Biol Chem. 1969 Oct 10;244(19):5403-13.

Aggregation states and catalytic properties of the multienzyme complex catalyzing the initial steps of pyrimidine biosynthesis in rat liver.大鼠肝脏中催化嘧啶生物合成起始步骤的多酶复合物的聚集状态及催化特性

Biochemistry. 1975 Jun 17;14(12):2622-30. doi: 10.1021/bi00683a010.

引用本文的文献

Controlled proteolysis of the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells: evidence for discrete structural domains.对启动哺乳动物细胞嘧啶生物合成的多功能蛋白质进行的可控蛋白水解：离散结构域的证据。

Proc Natl Acad Sci U S A. 1981 Nov;78(11):6647-51. doi: 10.1073/pnas.78.11.6647.

The effect of glutamine concentration on the activity of carbamoyl-phosphate synthase II and on the incorporation of [3H]thymidine into DNA in rat mesenteric lymphocytes stimulated by phytohaemagglutinin.谷氨酰胺浓度对大鼠肠系膜淋巴细胞中氨甲酰磷酸合成酶II活性以及对[3H]胸腺嘧啶核苷掺入DNA的影响，该淋巴细胞由植物血凝素刺激。

Biochem J. 1989 Aug 1;261(3):979-83. doi: 10.1042/bj2610979.

Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes.植物血凝素刺激的人淋巴细胞中的腺苷代谢

J Clin Invest. 1976 Sep;58(3):654-66. doi: 10.1172/JCI108512.

Purine metabolism in human lymphocytes.人类淋巴细胞中的嘌呤代谢。

Blut. 1979 Jun 18;38(6):447-55. doi: 10.1007/BF01013505.

Genetics and biochemistry of carbamoyl phosphate biosynthesis and its utilization in the pyrimidine biosynthetic pathway.氨甲酰磷酸生物合成的遗传学和生物化学及其在嘧啶生物合成途径中的利用。

Microbiol Rev. 1978 Jun;42(2):307-28. doi: 10.1128/mr.42.2.307-328.1978.

Fine structure of the URA2 locus in Saccharomyces cerevisiae. II. Meiotic and mitotic mapping studies.酿酒酵母URA2基因座的精细结构。II. 减数分裂和有丝分裂定位研究。

Mol Gen Genet. 1976 Jun 15;145(3):259-71. doi: 10.1007/BF00325822.

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