犬冠状动脉循环的大颗粒白蛋白研究
Macroaggregated albumin studies of the coronary circulation in the dog.
作者信息
Richmond D R, Yipintsoi T, Coulam C M, Titus J L, Bassingthwaighte J B
出版信息
J Nucl Med. 1973 Mar;14(3):129-34.
Abstract
The distribution, toxicity, and clearance of I-labeled macroaggregated albumin were studied in the coronary circulation of the dog. Twenty-five percent of the injected label traversed the coronary capillary bed within 3 min after injection and the biologic half-clearance time of the remainder was approximately 8 hr. After coronary artery injection of macroaggregate, no deterioration of left ventricular function was apparent from hemodynamic measurements, and no histologic evidence of myocardial damage was found after doses up to ten times the suggested diagnostic dose. The results of computer-controlled external scintiscans in the excised heart were shown as three-dimensional displays of count distribution.
摘要
研究了碘标记的大颗粒白蛋白在犬冠状动脉循环中的分布、毒性和清除情况。注射的标记物在注射后3分钟内有25%穿过冠状动脉毛细血管床，其余部分的生物半清除时间约为8小时。冠状动脉注射大颗粒后，血流动力学测量未显示左心室功能恶化，在剂量高达建议诊断剂量的10倍时，未发现心肌损伤的组织学证据。在离体心脏中进行的计算机控制外部闪烁扫描结果以计数分布的三维显示呈现。
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Macroaggregated albumin studies of the coronary circulation in the dog.犬冠状动脉循环的大颗粒白蛋白研究
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