新绿灰霉素的可控生物合成，绿灰霉素II的新同系物。新绿灰霉素II的生产、生物学特性及结构。

Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein II. Production, biological properties and structure of neoviridogrisein II.

作者信息

Okumura Y, Takei T, Sakamoto M, Ishikura T, Fukagawa Y

出版信息

J Antibiot (Tokyo). 1979 Jun;32(6):584-92. doi: 10.7164/antibiotics.32.584.

DOI:10.7164/antibiotics.32.584

Abstract

Our isolate of Streptomyces griseoviridus, which produced three minor factors in addition to viridogrisein and griseoviridus, which produced three minor factors in addition to viridogrisein and griseoviridin, was more sensitive to the addition of L-proline than the type culture of Streptomyces griseoviridus (NRRL2427). Yield improvement of these minor factors was attempted by the so-called controlled biosynthesis with L-proline. Addition of L-proline increased the production of neoviridogrisein II in which allo-hydroxy-D-proline in viridogrisein was replaced by D-proline.

摘要

我们分离得到的灰绿链霉菌除产生绿灰菌素和灰绿菌素外，还产生三种次要因子，该菌株比灰绿链霉菌模式菌株（NRRL2427）对添加L-脯氨酸更为敏感。我们尝试通过所谓的L-脯氨酸控制生物合成来提高这些次要因子的产量。添加L-脯氨酸增加了新绿灰菌素II的产量，其中绿灰菌素中的别羟基-D-脯氨酸被D-脯氨酸取代。