Musick W D, Rossmann M G
J Biol Chem. 1979 Aug 25;254(16):7621-3.
A tentative amino acid sequence of mouse testicular lactate dehydrogenase C4 was deduced from an electron density map and comparison with five other known lactate dehydrogenase sequences. The amino acid composition determined by chemical analysis agrees reasonably well with the present results. Necessary changes in amino acids were largely conservative and confined to the external portions of the molecule. Residues in the Q and P subunit contact regions were particularly well conserved as were most internal residues. The minimum base change/codon was similar between the C and H isoenzymes and between the C and M isoenzymes.
从小鼠睾丸乳酸脱氢酶C4的电子密度图以及与其他五个已知乳酸脱氢酶序列的比较中，推导得出了一个初步的氨基酸序列。通过化学分析确定的氨基酸组成与目前的结果相当吻合。氨基酸的必要变化大多是保守的，且局限于分子的外部区域。Q和P亚基接触区域的残基以及大多数内部残基都特别保守。C同工酶与H同工酶之间以及C同工酶与M同工酶之间的最小碱基变化/密码子相似。
