心力衰竭患儿的血浆地高辛浓度。
Plasma digoxin concentration in children with heart failure.
作者信息
Cree J E, Coltart D J, Howard M R
出版信息
Br Med J. 1973 Feb 24;1(5851):443-4. doi: 10.1136/bmj.1.5851.443.
Abstract
A dosage schedule for digoxin medication is presented which has proved effective and safe in children of different ages with heart failure due to a variety of cardiac conditions. The plasma digoxin concentrations during maintenance therapy, using this schedule, agree closely with previously reported therapeutic adult plasma concentrations, though the results do not exclude the efficiency and safety of higher doses. A twice-daily dosage regimen is suggested.
摘要
本文给出了地高辛药物的给药方案，该方案已被证明对因各种心脏疾病导致心力衰竭的不同年龄段儿童有效且安全。采用此方案进行维持治疗期间的血浆地高辛浓度与先前报道的成人治疗血浆浓度密切相符，不过结果并不排除更高剂量的有效性和安全性。建议采用每日两次的给药方案。
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引用本文的文献
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Digoxin dosage schedules for neonates and infants based on pharmacokinetic considerations.
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本文引用的文献
1
Digoxin dosage in premature infants.早产儿的地高辛剂量。
Pediatrics. 1962 Jan;29:18-25.
2
Digitalis intoxication. A prospective clinical study with serum level correlations.洋地黄中毒。一项血清水平相关性的前瞻性临床研究。
N Engl J Med. 1971 May 6;284(18):989-97. doi: 10.1056/NEJM197105062841801.
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Plasma digoxin concentrations in patients with atrial fibrillation.心房颤动患者的血浆地高辛浓度。
Br Med J. 1970 Aug 22;3(5720):429-32. doi: 10.1136/bmj.3.5720.429.
4
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.采用放射免疫分析法测定治疗性和中毒性血清地高辛浓度。
N Engl J Med. 1969 Nov 27;281(22):1212-6. doi: 10.1056/NEJM196911272812203.
5
Effects of digoxin on systolic time intervals of neonates and infants.地高辛对新生儿和婴儿收缩期时间间期的影响。
Circulation. 1972 Oct;46(4):816-23. doi: 10.1161/01.cir.46.4.816.
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