Hellier M D, Thirumalai C, Holdsworth C D
Gut. 1973 Jan;14(1):41-5. doi: 10.1136/gut.14.1.41.
A perfusion technique has been used to quantitate the effect of the amino acids glycine and alanine and the dipeptides glycyl-glycine and glycyl-L-alanine on sodium and water absorption from the human jejunum. Although no net absorption of sodium and water was seen in the absence of non-electrolytes, a significant stimulation occurred in the presence of both free amino acids and dipeptides. In the case of glycine and alanine, sodium and water absorption increased linearly with increasing concentration of the amino acid and saturation was not demonstrated over the range of concentrations studied. Molar ratios for net absorption of free amino acid and sodium were approximately 1:1 for all but the highest concentration of alanine. In contrast, the corresponding molar ratios for the two dipeptide solutions and sodium were approximately 1:2. Possible explanations for these observations are discussed.
一种灌注技术已被用于定量氨基酸甘氨酸和丙氨酸以及二肽甘氨酰甘氨酸和甘氨酰-L-丙氨酸对人空肠钠和水吸收的影响。尽管在不存在非电解质的情况下未观察到钠和水的净吸收，但在游离氨基酸和二肽存在时会出现显著的刺激作用。就甘氨酸和丙氨酸而言，钠和水的吸收随氨基酸浓度的增加呈线性增加，在所研究的浓度范围内未表现出饱和现象。除丙氨酸最高浓度外，游离氨基酸与钠净吸收的摩尔比在所有情况下均约为1:1。相比之下，两种二肽溶液与钠的相应摩尔比约为1:2。文中讨论了对这些观察结果的可能解释。
