单纯性尿道下裂的流行病学观察
Observations on the epidemiology of simple hypospadias.
作者信息
Roberts C J, Lloyd S
出版信息
Br Med J. 1973 Mar 31;1(5856):768-70. doi: 10.1136/bmj.1.5856.768.
Abstract
A descriptive epidemiological study of simple hypospadias-that is, hypospadias without coexisting malformation outside the genital system-in a birth population of 46,927 singleton males and 1,013 twin males showed that the condition was significantly more common (P < 0.001) in uniovular twin males than in either singleton or binovular twin males. Also the temporal distribution of dates of conception had a significant cyclic pattern for each year of the study. Both observations are thought to support the view that gonadotrophin levels at stage 3 sexual organogenesis play an important part in normal masculinization of male external genitalia.
摘要
一项针对46927名单胎男性和1013对双胞胎男性出生人群的单纯性尿道下裂（即不伴有生殖系统外并存畸形的尿道下裂）的描述性流行病学研究表明，单卵双胞胎男性患该病的比例显著高于单胎或双卵双胞胎男性（P < 0.001）。此外，在研究的每一年中，受孕日期的时间分布都呈现出显著的周期性模式。这两个观察结果都被认为支持这样一种观点，即性器官发生第3阶段的促性腺激素水平在男性外生殖器的正常男性化过程中起着重要作用。
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