Greenstein B D
J Endocrinol. 1979 Apr;81(1):75-81. doi: 10.1677/joe.0.0810075.
Available high-affinity binding sites for 5 alpha-dihydrotestosterone (DHT) were measured in cytosols obtained from the amygdala, hypothalamus, anterior pituitary gland and ventral prostate gland of 12-week-old rats at various times after orchidectomy, and in the corresponding tissues of 18-month-old male rats. It is suggested that the lower affinity of the DHT binding reaction in brain and ventral prostatic cytosols after orchidectomy or ageing respectively, may explain, at least in part, the changes in the responsiveness of the tissues to androgens.
在切除睾丸后不同时间点，对12周龄大鼠的杏仁核、下丘脑、垂体前叶和腹侧前列腺以及18月龄雄性大鼠相应组织的胞质溶胶中5α-双氢睾酮（DHT）的高亲和力结合位点进行了测定。结果表明，切除睾丸或衰老后，脑和腹侧前列腺胞质溶胶中DHT结合反应的亲和力降低，这可能至少部分解释了组织对雄激素反应性的变化。
