van Zwieten M J, Burek J D, Zurcher C, Hollander C F
J Pathol. 1979 Jun;128(2):99-112. doi: 10.1002/path.1711280208.
The histologic features of aortic body neoplasia, hyperplasia, and normal aortico-pulmonary paraganglia were described for a series of 56 rats of several strains. Argyrophilic cytoplasmic granules were demonstrated in chief cells of the aortic body lesions, and electron microscopic examination disclosed the presence of electron-dense, membrane-bound granules in these cells. In a series of ageing rats, hyperplasia and neoplasia of the aortico-pulmonary paraganglia occurred more frequently in female WAG/Rij rats than in males of that strain, and more frequently than in males and females of the BN/Bi strain or of the (WAG X BN)F1 hybrid. No apparent causal relationship to chronic hypoxia could be shown, in that no correlation between the development of aortic body neoplasia or hyperplasia and cardiopulmonary disease was found. Aortic body lesions did not appear to occur as part of a multiple endocrinopathy syndrome, although hyperplasia and neoplasia of various endocrine organs occurred relatively frequently in the WAG/Rij strain.
描述了一系列56只不同品系大鼠的主动脉体肿瘤形成、增生以及正常主动脉-肺副神经节的组织学特征。在主动脉体病变的主细胞中显示出嗜银性细胞质颗粒，电子显微镜检查揭示这些细胞中存在电子致密的、膜结合颗粒。在一系列老龄大鼠中，主动脉-肺副神经节的增生和肿瘤形成在雌性WAG/Rij大鼠中比该品系的雄性大鼠更频繁发生，并且比BN/Bi品系或（WAG×BN）F1杂交种的雄性和雌性大鼠更频繁。未显示出与慢性缺氧有明显因果关系，因为在主动脉体肿瘤形成或增生的发展与心肺疾病之间未发现相关性。尽管各种内分泌器官的增生和肿瘤形成在WAG/Rij品系中相对频繁发生，但主动脉体病变似乎并非作为多内分泌病综合征的一部分出现。
