Desjardins L, Blajchman M A, Chintu C, Gent M, Zipursky A
J Pediatr. 1979 Sep;95(3):447-9. doi: 10.1016/s0022-3476(79)80533-8.
A series of 1,704 infants of blood group O mothers have been studied to determine the relation between the degree of red cell sensitization and the cord hemoglobin and bilirubin concentrations. The infants with blood group A or B had significantly higher cord bilirubin and lower cord hemoglobin concentrations than the group O babies. Those infants whose red cells had the greatest evidence of sensitization had the highest bilirubin and lowest hemoglobin levels. The infants in whom no antibody was demonstrable on the red cells or in the red cell eluate also had significantly higher cord bilirubin and lower cord hemoglobin levels than the ABO compatible group; it is suggested that these infants had sufficient erythrocyte sensitization to produce mild hemolysis. ABO incompatibility represents a spectrum of hemolytic disease extending from those in which there is little laboratory evidence of erythrocyte sensitization, but evidence of hemolysis, to severe hemolytic disease in which erythrocyte sensitization is usually easily demonstrable.
对1704名母亲为O血型的婴儿进行了一系列研究，以确定红细胞致敏程度与脐血血红蛋白及胆红素浓度之间的关系。A型或B型血的婴儿脐血胆红素浓度显著高于O型血婴儿，脐血血红蛋白浓度则低于O型血婴儿。红细胞致敏证据最明显的婴儿，其胆红素水平最高，血红蛋白水平最低。红细胞或红细胞洗脱液中未检测到抗体的婴儿，其脐血胆红素浓度也显著高于ABO血型相容组，脐血血红蛋白水平则低于该组；提示这些婴儿有足够的红细胞致敏，从而导致轻度溶血。ABO血型不相容代表了一系列溶血性疾病，范围从几乎没有红细胞致敏的实验室证据但有溶血证据的情况，到通常很容易检测到红细胞致敏的严重溶血性疾病。
