Sullivan J L, Smith F A, Garman R H
J Reprod Fertil. 1979 May;56(1):201-7. doi: 10.1530/jrf.0.0560201.
Rats recieving 20, 6.6 or 2.2 p.p.m. sodium fluoroacetate in the drinking water were killed daily during the 7 days of treatment and at more widely spaced intervals in the succeeding 21 days. Testicular weight and ATP concentrations decreased in rats receiving 20 or 6 p.p.m. fluoroacetate, while citrate concentrations were elevated and morphological damage was seen in the testes of all the treated rats. Initial cellular changes common to the three treatment groups included altered appearance and decreased numbers of spermatids, and formation of spermatid and spermatocyte giant cells. At the two higher concentrations damage progressed to marked seminiferous tubule atrophy. Regeneration of the seminiferous tubules was complete by 7 days after treatment, in the rats given 2 p.p.m. but regeneration was not complete by Day 21 after treatment in those receiving the higher doses. Spermatogenesis was abnormal in some instances during the regneration period in these groups. The findings are consistent with impaired energy production via blockage of the Krebs cycle, and subsequent impairment of carbohydrate metabolism through the Embden-Meyerhof pathway.
给饮用水中添加20、6.6或2.2 ppm氟乙酸钠的大鼠，在治疗的7天内每天处死，并在随后的21天以更大的间隔处死。接受20或6 ppm氟乙酸钠的大鼠睾丸重量和ATP浓度降低，而所有处理组大鼠睾丸中的柠檬酸盐浓度升高且可见形态学损伤。三个处理组共有的初始细胞变化包括精子细胞外观改变、数量减少，以及精子细胞和精母细胞巨细胞的形成。在两个较高浓度下，损伤进展为明显的生精小管萎缩。给予2 ppm氟乙酸钠的大鼠，生精小管在治疗后7天完全再生，但接受较高剂量的大鼠在治疗后第21天再生仍未完成。在这些组的再生期，某些情况下精子发生异常。这些发现与通过阻断三羧酸循环导致能量产生受损，以及随后通过糖酵解途径导致碳水化合物代谢受损一致。
