Marsheck W J, Karim A
Appl Microbiol. 1973 Apr;25(4):647-9. doi: 10.1128/am.25.4.647-649.1973.
It has been postulated that 3-(3-oxo-7alpha-methylthio-4-androsten-17alpha-yl)propionic acid gamma-lactone (I) is a key intermediate in the metabolism of the anti-aldosterone agent, spironolactone (3-[3-oxo-7alpha-acetylthio-17beta-hydroxy-4-androsten-17alpha-yl] propionic acid gamma-lactone). In the present study it was found that microbial oxygenation of I by Chaetomium cochloides QM 624 gave three metabolites which retained sulfur in their molecules and were found to be identical to the human metabolites of spironolactone.
据推测，3-(3-氧代-7α-甲硫基-4-雄甾烯-17α-基)丙酸γ-内酯（I）是抗醛固酮剂螺内酯（3-[3-氧代-7α-乙酰硫基-17β-羟基-4-雄甾烯-17α-基]丙酸γ-内酯）代谢过程中的关键中间体。在本研究中发现，球毛壳菌QM 624对I进行微生物氧化产生了三种分子中保留硫的代谢产物，并且发现它们与螺内酯的人体代谢产物相同。
