Wakefield J, Yule R, Smith A, Adelstein A M
Br Med J. 1973 Apr 21;2(5859):142-3. doi: 10.1136/bmj.2.5859.142.
An analysis of the cytological records of almost 300,000 women in the Manchester area shows that the rates of positive/suspicious findings from population screening are highly correlated with the rates of mortality from cancer of the cervix when both are distributed according to the occupation of the husband. The correlation holds for various occupational groupings and for all the individual occupation units in which there are more than 1,000 women. This evidence strengthens the case for believing that the condition revealed by a positive smear is a stage in the development of invasive cancer of the uterine cervix.
对曼彻斯特地区近30万名女性的细胞学记录分析表明，当按丈夫职业分布时，人群筛查中阳性/可疑结果的发生率与宫颈癌死亡率高度相关。这种相关性适用于各种职业分组以及所有女性人数超过1000人的个体职业单位。这一证据进一步证明，涂片阳性所显示的状况是子宫颈浸润癌发展过程中的一个阶段。
