Dubach U C, Rosner B, Müller A, Levy P S, Baumeler H R, Peier A, Ehrensperger T
Lancet. 1975 Mar 8;1(7906):539-43. doi: 10.1016/s0140-6736(75)91557-3.
A study group of 623 employed Swiss women aged 30-49 years showing objective evidence of intake of phenacetin-containing analgesics, and a control group of 621 comparable women showing no such intake, were observed for 4 years (1969-72) for laboratory evidence of urorenal disorders. In both study and control groups morbidity was low. There was no difference between the study and control groups with respect to subsequent proteinuria, bacteriuria, and haematuria. The 4-year incidence of low urine specific gravity after overhight thirsting was significantly higher in the study group than in the control group (3-8% v. 0-8%) and the incidence of raised serum-creatinine was also significantly higher in the study group (2-9% v. 0-4%). However, when the study group was further subdivided into a sub-group showing evidence of high intake of phenacetincontaining analgesics and one showing low intake, only the high-intake subgroup had an incidence of raised serum-creatinine (5-4%) significantly higher than the control group (0-4%), whereas the low-intake subgroup had an incidence (0-4%) similar to the control group.
一个研究小组对623名年龄在30至49岁、有服用含非那西丁镇痛药客观证据的在职瑞士女性进行了观察，并设立了一个由621名情况类似但未服用此类药物的女性组成的对照组，对她们进行了4年（1969 - 1972年）的观察，以获取泌尿肾脏疾病的实验室证据。研究组和对照组的发病率都很低。在后续蛋白尿、菌尿和血尿方面，研究组和对照组之间没有差异。在过度口渴后，研究组低尿比重的4年发病率显著高于对照组（3 - 8%对0 - 8%），研究组血清肌酐升高的发病率也显著高于对照组（2 - 9%对0 - 4%）。然而，当研究组进一步细分为显示高剂量服用含非那西丁镇痛药证据的亚组和低剂量服用的亚组时，只有高剂量摄入亚组血清肌酐升高的发病率（5 - 4%）显著高于对照组（0 - 4%），而低剂量摄入亚组的发病率（0 - 4%）与对照组相似。
