Suttie J W
Science. 1973 May 18;180(4087):741-3. doi: 10.1126/science.180.4087.741.
Strains of wild rats that are resistant to the anticoagulant action of coumarins and derivatives of indandione have been discovered in a number of geographic areas. These rats have now been shown to be more susceptible than normal rats are to the anticoagulant action of the vitamin K antagonist, 2-chloro-3-phytyl-1,4-naphthoquinone. This compound, either alone or in combination with warfarin, would appear to be an effective rodenticide in areas where resistance to the indirect anticoagulants is a problem.
在许多地理区域都发现了对香豆素和茚二酮衍生物的抗凝血作用具有抗性的野生大鼠品系。现已表明，这些大鼠比正常大鼠更容易受到维生素K拮抗剂2-氯-3-植基-1,4-萘醌的抗凝血作用影响。这种化合物单独使用或与华法林联合使用，在存在对间接抗凝血剂产生抗性问题的地区似乎是一种有效的灭鼠剂。
