一家儿科医院患者中遗传病和先天性畸形的发生率。
The frequency of genetic disease and congenital malformation among patients in a pediatric hospital.
作者信息
Scriver C R, Neal J L, Saginur R, Clow A
出版信息
Can Med Assoc J. 1973 May 5;108(9):1111-5.
A sample of 12,801 admissions to a pediatric hospital was surveyed in 1969-70 to determine the prevalence of disease which could be classified as "genetic" in origin or related to "congenital malformation"."Genetic" admissions accounted for 11.1% of the total while 18.5% were for congenital malformations; about 2% (unknown group) were probably genetic. Therefore about one third of all admissions represent the effect of abnormal gene-environment interrelations at some point in the development or life of the patient.The "genetic" patient is admitted more often to a medical service while the patient with congenital malformation usually goes to a surgical service; the former stays 7.3 days and the latter 8.6 days. A disproportionate number of patients staying longer than 10 days were found in the group with congenital malformations. Seventy percent of the patients with multiple admissions (3.2% of all admissions) have genetic illness or congenital malformation.
1969年至1970年期间，对一家儿童医院的12801例入院病例进行了调查，以确定可归类为“遗传性”起源或与“先天性畸形”相关的疾病的患病率。“遗传性”入院病例占总数的11.1%，而先天性畸形病例占18.5%；约2%（不明组）可能是遗传性的。因此，所有入院病例中约有三分之一代表了患者发育或生命中某个阶段异常基因与环境相互作用的影响。“遗传性”患者更多地入住内科，而先天性畸形患者通常入住外科；前者住院7.3天，后者住院8.6天。在先天性畸形组中，发现住院时间超过10天的患者比例过高。多次入院的患者中有70%（占所有入院病例的3.2%）患有遗传性疾病或先天性畸形。
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