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利用放射自显影术和秋水仙酰胺诱导的有丝分裂停滞对豚鼠胸腺中有丝分裂活性位点进行的研究。

An investigation of the sites of mitotic activity in the guinea-pig thymus using autoradiography and colcemid-induced mitotic arrest.

作者信息

Poste M E, Olson I A

出版信息

Immunology. 1973 Apr;24(4):691-7.

PMID:4706565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1422892/
Abstract

Tritiated thymidine autoradiographs prepared from sections of guinea-pig thymus were compared with sections from animals treated with the mitotic arresting drug Colcemid. Autoradiography demonstrated the existence of two synthesizing zones, the previously described subcapsular cortex and a new zone of activity, the corticomedullary junction. The existence of these zones was confirmed quantitatively in the Colcemid-treated animals.

摘要

将豚鼠胸腺切片制备的氚标记胸腺嘧啶核苷放射自显影片与用有丝分裂阻断药物秋水仙酰胺处理的动物的切片进行了比较。放射自显影显示存在两个合成区，即先前描述的被膜下皮质和一个新的活性区，即皮质髓质交界处。在秋水仙酰胺处理的动物中定量证实了这些区域的存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab13/1422892/32b232d02809/immunology00339-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab13/1422892/32b232d02809/immunology00339-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab13/1422892/32b232d02809/immunology00339-0100-a.jpg

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引用本文的文献

1
Have we underestimated the importance of the thymus in man?我们是否低估了胸腺在人类中的重要性？
Experientia. 1984 Nov 15;40(11):1181-5. doi: 10.1007/BF01946644.

本文引用的文献

1
[AUTORADIOGRAPHIC STUDIES ON THE UPTAKE AND DISTRIBUTION OF TRITIATED THYMIDINE IN THE THYMUS GLAND OF MICE].[氚标记胸腺嘧啶核苷在小鼠胸腺中摄取与分布的放射自显影研究]
Verh Anat Ges. 1964;59:122-30.
2
Tentative pattern for renewal of lymphocytes in cortex of the rat thymus.大鼠胸腺皮质中淋巴细胞更新的初步模式。
Proc Soc Exp Biol Med. 1958 Feb;97(2):263-70. doi: 10.3181/00379727-97-23710.
3
[Electron microscopic radioautography with H3-thymidine of the thymus cortex of the mouse].
Z Zellforsch Mikrosk Anat. 1966;72(3):281-94.
4
[Cell divisions and cell migrations in the thymus of the adult mouse].[成年小鼠胸腺中的细胞分裂与细胞迁移]
Z Zellforsch Mikrosk Anat. 1965 Oct 28;68(3):427-44.
5
Mitotic studies in thyroxin-stimulated thymo-lymphatic tissue. An investigation in guinea-pigs with the colchicine technique.甲状腺素刺激的胸腺淋巴组织中的有丝分裂研究。用秋水仙碱技术对豚鼠进行的一项研究。
Acta Pathol Microbiol Scand. 1965;65(2):215-20. doi: 10.1111/apm.1965.65.2.215.
6
Pattern of cell production and cell migration in mouse thymus studied by autoradiography.通过放射自显影术研究小鼠胸腺中的细胞产生模式和细胞迁移。
Scand J Haematol. 1968;5(5):339-52. doi: 10.1111/j.1600-0609.1968.tb01758.x.
7
Incorporation of sulfate by the mouse thymus: its relation to secretion by medullary epithelial cells and to thymic lymphopoiesis.小鼠胸腺对硫酸盐的摄取：其与髓质上皮细胞分泌及胸腺淋巴细胞生成的关系。
J Exp Med. 1968 Nov 1;128(5):927-57. doi: 10.1084/jem.128.5.927.
8
Effects of antithymus serum on thymic lymphopoiesis: a radioautographic study.抗胸腺血清对胸腺淋巴细胞生成的影响：一项放射自显影研究。
J Immunol. 1969 Oct;103(4):778-86.
9
Labelling of the rat thymus by intramediastinal injection of tritiated thymidine.通过纵隔内注射氚标记胸腺嘧啶核苷对大鼠胸腺进行标记。
Rev Can Biol. 1969 Sep;28(3):205-8.
10
Thymus and node labelling by intramediastinal injection of tritiated tracers and its bearing on present concepts of lymphocyte cytokinetics.通过纵隔内注射氚标记示踪剂对胸腺和淋巴结进行标记及其与当前淋巴细胞动力学概念的关系
Scand J Haematol. 1970;7(3):163-76. doi: 10.1111/j.1600-0609.1970.tb01884.x.