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1
Bile acids and vitamin A absorption in man: the effects of two bile acid-binding agents, cholestyramine and lignin.人体中胆汁酸与维生素A的吸收：两种胆汁酸结合剂——考来烯胺和木质素的作用
Gut. 1973 Apr;14(4):316-8. doi: 10.1136/gut.14.4.316.
2
Comparison of two bile acid-binding agents, cholestyramine and lignin.两种胆汁酸结合剂，消胆胺和木质素的比较。
Clin Sci. 1970 Apr;38(4):25P. doi: 10.1042/cs038025p.
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Effect of cholestyramine on the absorption of vitamin D3 and calcium.消胆胺对维生素D3和钙吸收的影响。
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Effect of cholestyramine on bile acid metabolism in normal man.消胆胺对正常人胆汁酸代谢的影响。
J Clin Invest. 1972 Nov;51(11):2781-9. doi: 10.1172/JCI107100.
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Effect of cholestyramine on fecal bile salt excretion in rats fed diets containing medium-chain triglycerides or corn oil.消胆胺对喂食含中链甘油三酯或玉米油饮食的大鼠粪便胆汁盐排泄的影响。
Proc Soc Exp Biol Med. 1973 May;143(1):93-6. doi: 10.3181/00379727-143-37260.
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'Enteral' hyperoxaluria. Effect of cholestyramine, calcium, neomycin, and bile acids on intestinal oxalate absorption in man.“肠源性”高草酸尿症。消胆胺、钙、新霉素及胆汁酸对人体肠道草酸吸收的影响
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Preferential retention of taurine-conjugated bile salts by cholestyramine in the rat ileum.
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Absorption of dietary fats by the rat in cholestyramine-induced steatorrhea.
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Role of fat maldigestion in pathogenesis of steatorrhea in ileal resection. Fat digestion after two sequential test meals with and without cholestyramine.脂肪消化不良在回肠切除术后脂肪泻发病机制中的作用。服用和未服用消胆胺的两次连续试验餐后的脂肪消化情况。
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Comparison of the effects of cholestyramine and aluminium hydroxide on the biliary bile acid excretion in rats. An experimental model for the depletion of bile acids in bile.
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Gut microbiota derived metabolites in cardiovascular health and disease.肠道微生物衍生代谢物与心血管健康和疾病。
Protein Cell. 2018 May;9(5):416-431. doi: 10.1007/s13238-018-0549-0. Epub 2018 May 3.
2
Lignins and Their Derivatives with Beneficial Effects on Human Health.对人体健康有有益影响的木质素及其衍生物。
Int J Mol Sci. 2017 Jun 7;18(6):1219. doi: 10.3390/ijms18061219.
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Lignosulfonic acid promotes hypertrophy in 3T3-L1 cells without increasing lipid content and increases their 2-deoxyglucose uptake.木质素磺酸可促进3T3-L1细胞肥大，而不增加脂质含量，并增加其2-脱氧葡萄糖摄取。
Asian-Australas J Anim Sci. 2017 Jan;30(1):111-118. doi: 10.5713/ajas.16.0253. Epub 2016 Jun 30.
4
Effects of the fibre components pectin, cellulose, and lignin on bile salt metabolism and biliary lipid composition in man.膳食纤维成分果胶、纤维素和木质素对人体胆汁盐代谢及胆汁脂质成分的影响。
Gut. 1986 Jan;27(1):29-36. doi: 10.1136/gut.27.1.29.

本文引用的文献

1
Studies on the adsorption of bile salts to non-absorbed components of diet.关于胆汁盐对饮食中未吸收成分吸附作用的研究。
Biochim Biophys Acta. 1968 Jan 10;152(1):165-73. doi: 10.1016/0005-2760(68)90018-0.
2
An in vivo comparison of two bile salt binding agents, cholestyramine and lignin.两种胆盐结合剂（消胆胺和木质素）的体内比较。
Scand J Gastroenterol. 1971;6(3):281-6. doi: 10.3109/00365527109180709.
3
[Treatment of no. II type essential hyperlipoproteinemia with a new therapeutic agent, celluline].[一种新型治疗药物纤维素对Ⅱ型原发性高脂蛋白血症的治疗]
Can Med Assoc J. 1970 Jul 18;103(2):165-6.
4
Quantification of the binding tendencies of cholestyramine. II. Mechanism of interaction with bile salt and fatty acid salt anions.消胆胺结合倾向的定量分析。II. 与胆盐和脂肪酸盐阴离子的相互作用机制。
J Pharm Sci. 1970 Mar;59(3):329-33. doi: 10.1002/jps.2600590311.
5
Hypoprothrombinemia and hemorrhage associated with cholestyramine therapy.与消胆胺治疗相关的低凝血酶原血症和出血。
Ann Intern Med. 1970 Jan;72(1):95-6. doi: 10.7326/0003-4819-72-1-95.
6
Osteomalacia associated with cholestyramine therapy for postileectomy diarrhea.考来烯胺治疗术后腹泻所致的骨软化症
Gastroenterology. 1972 Apr;62(4):642-6.
7
Lignin: a bile-salt sequestrating agent.木质素：一种胆汁盐螯合剂。
Lancet. 1968 Nov 30;2(7579):1170-2. doi: 10.1016/s0140-6736(68)91643-7.

人体中胆汁酸与维生素A的吸收：两种胆汁酸结合剂——考来烯胺和木质素的作用

Bile acids and vitamin A absorption in man: the effects of two bile acid-binding agents, cholestyramine and lignin.

作者信息

Barnard D L, Heaton K W

出版信息

Gut. 1973 Apr;14(4):316-8. doi: 10.1136/gut.14.4.316.

DOI:10.1136/gut.14.4.316
PMID:4706914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412596/
Abstract

In 14 healthy volunteers, the addition of 12 g cholestyramine to a vitamin A-containing test meal reduced the expected rise in serum vitamin A by 59.5% (p<0.001). By contrast, lignin had no significant effect in 12 subjects. This study confirms the importance of bile acids in vitamin A absorption and the ineffectiveness of lignin as a sequestrator of conjugated bile acids.

摘要

在14名健康志愿者中，在含维生素A的试验餐中添加12克消胆胺使血清维生素A的预期升高降低了59.5%（p<0.001）。相比之下，木质素在12名受试者中没有显著影响。这项研究证实了胆汁酸在维生素A吸收中的重要性以及木质素作为结合胆汁酸螯合剂的无效性。