阿托品对人瞳孔括约肌中毒蕈碱受体的亲和力。
The affinity of atropine for muscarine receptors in human sphincter pupillae.
作者信息
Kaumann A J, Hennekes R
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):209-11. doi: 10.1007/BF00507105.
PMID:471075
Abstract
Concentration-dependent contractions in response to carbachol were determined on isolated pieces of human iris. Atropine competivtively antagonized the effect of carbachol. An apparent dissociation equilibrium constant of 0.4--0.7 nM was estimated for the muscarine receptor-atropine complex.
摘要
在离体的人虹膜组织上测定了对卡巴胆碱的浓度依赖性收缩反应。阿托品竞争性拮抗卡巴胆碱的作用。毒蕈碱受体 - 阿托品复合物的表观解离平衡常数估计为0.4 - 0.7 nM。
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