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阿托品对人瞳孔括约肌中毒蕈碱受体的亲和力。

The affinity of atropine for muscarine receptors in human sphincter pupillae.

作者信息

Kaumann A J, Hennekes R

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):209-11. doi: 10.1007/BF00507105.

DOI:10.1007/BF00507105
PMID:471075
Abstract

Concentration-dependent contractions in response to carbachol were determined on isolated pieces of human iris. Atropine competivtively antagonized the effect of carbachol. An apparent dissociation equilibrium constant of 0.4--0.7 nM was estimated for the muscarine receptor-atropine complex.

摘要

在离体的人虹膜组织上测定了对卡巴胆碱的浓度依赖性收缩反应。阿托品竞争性拮抗卡巴胆碱的作用。毒蕈碱受体 - 阿托品复合物的表观解离平衡常数估计为0.4 - 0.7 nM。

相似文献

1
The affinity of atropine for muscarine receptors in human sphincter pupillae.阿托品对人瞳孔括约肌中毒蕈碱受体的亲和力。
Naunyn Schmiedebergs Arch Pharmacol. 1979 Apr;306(3):209-11. doi: 10.1007/BF00507105.
2
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M2 muscarinic receptor subtype is associated with inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris.M2毒蕈碱受体亚型与兔虹膜括约肌平滑肌中的三磷酸肌醇积累、肌球蛋白轻链磷酸化及收缩相关。
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引用本文的文献

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Muscarinic inhibition of [3H]-noradrenaline release on rabbit iris in vitro: effects of stimulation conditions on intrinsic activity of methacholine and pilocarpine.毒蕈碱对体外培养的兔虹膜中[3H]-去甲肾上腺素释放的抑制作用：刺激条件对乙酰甲胆碱和毛果芸香碱内在活性的影响。
Br J Pharmacol. 1988 Jul;94(3):890-900. doi: 10.1111/j.1476-5381.1988.tb11601.x.
3
Receptor-responses in fresh human ciliary muscle.

本文引用的文献

1
THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS.豚鼠肠道平滑肌对阿托品及相关药物的摄取与乙酰胆碱受体的关系
Proc R Soc Lond B Biol Sci. 1965 Aug 24;163:1-44. doi: 10.1098/rspb.1965.0058.
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Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
3
A modification of receptor theory.受体理论的一种修正。
新鲜人睫状肌中的受体反应。
Br J Pharmacol. 1986 Feb;87(2):379-85. doi: 10.1111/j.1476-5381.1986.tb10827.x.
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Investigation by NMR spectroscopy of the interaction between synthetic soluble (-)-dopa melanin and drugs.通过核磁共振光谱法研究合成可溶性（-）-多巴黑色素与药物之间的相互作用。
Naunyn Schmiedebergs Arch Pharmacol. 1989 Nov;340(5):576-82. doi: 10.1007/BF00260613.
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Reactivity of human iris-sphincter to muscarinic drugs in vitro.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):614-9. doi: 10.1007/BF00168733.
Br J Pharmacol Chemother. 1956 Dec;11(4):379-93. doi: 10.1111/j.1476-5381.1956.tb00006.x.
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Convenient apparatus for recording contractions of isolated heart muscle.用于记录离体心肌收缩的便捷仪器。
J Appl Physiol. 1965 Jul;20(4):755-7. doi: 10.1152/jappl.1965.20.4.755.
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The rate of action of atropine.阿托品的作用速率。
J Pharmacol Exp Ther. 1968 Mar;160(1):91-105.
6
A comparison of the affinities of antagonists for acetylcholine receptors in the ileum, bronchial muscle and iris of the guinea-pig.豚鼠回肠、支气管肌肉和虹膜中拮抗剂对乙酰胆碱受体亲和力的比较。
Br J Pharmacol. 1972 Oct;46(2):300-12. doi: 10.1111/j.1476-5381.1972.tb06875.x.
7
Factors determining the potency of mydriatic drugs in man.决定散瞳药物对人体药效的因素。
Br J Clin Pharmacol. 1976 Jun;3(3):503-7. doi: 10.1111/j.1365-2125.1976.tb00628.x.