Piekarski L, Sawicki J, Kugaczewska M, Potocki L J, Sankowski A, Uszyński H, Małunowicz E, Wojciechowska M, Kolodziejska A, Fox C H
Neoplasma. 1979;26(2):139-44.
The effect of the antioxidant butylated hydroxyanisole (BHA) on benzo(a)pyrene (BP) metabolites binding to DNA, percentage of diols and phenols in the total amount of BP metabolites extracted to organic solvent, were studied in : incubation mixture of rat liver microsomes, cultured mouse embryo cells, human skin, and human lymphocytes. The amount of BP metabolites bound to DNA in mouse embryo cells and human skin decreased in the presence of BHA. No effect was found in human lymphocytes. Percent of phenols increased in mouse embryo cell cultures; percent of diols decreased in cultures of human skin and lymphocytes.
在大鼠肝微粒体、培养的小鼠胚胎细胞、人类皮肤和人类淋巴细胞的孵育混合物中，研究了抗氧化剂丁基羟基茴香醚（BHA）对苯并（a）芘（BP）代谢物与DNA结合的影响，以及BP代谢物提取到有机溶剂中的总量中二醇和酚的百分比。在BHA存在的情况下，小鼠胚胎细胞和人类皮肤中与DNA结合的BP代谢物量减少。在人类淋巴细胞中未发现影响。在小鼠胚胎细胞培养物中酚的百分比增加；在人类皮肤和淋巴细胞培养物中二醇的百分比降低。
