Tweeddale M G, Fodor J G
Nephron. 1979;23 Suppl 1:3-6. doi: 10.1159/000181660.
A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart disease remains controversial and the association of these two factors may depend on the relationship between uric acid and hypertension. There is no evidence available to define the metabolic turnover of uric acid in hypertensives. The exact mechanisms underlying elevated serum uric acid values during diuretic treatment are unclear, but depend initially upon diuretic-induced extracellular volume depletion.
对文献的批判性综述表明，血清尿酸升高肯定与高血压相关，并且可能是该疾病发展中的一个独立危险因素。血清尿酸升高作为缺血性心脏病发展的独立危险因素的可能作用仍存在争议，这两个因素之间的关联可能取决于尿酸与高血压之间的关系。目前尚无证据可确定高血压患者尿酸的代谢周转情况。利尿剂治疗期间血清尿酸值升高的具体机制尚不清楚，但最初取决于利尿剂引起的细胞外液容量减少。
