Collins R E, Fell R H, Lord P H
Br Med J. 1973 May 26;2(5864):457-9. doi: 10.1136/bmj.2.5864.457.
Manual dilatation of the anus was carried out on 50 unpremedicated outpatients under propanidid, nitrous oxide, and halothane anaesthesia with E.C.G.monitoring. About half of the patients received intravenous atropine with the propanidid. The operation induced a variety of changes in heart rate but in the whole experiment only two isolated cardiac arrhythmic complexes were seen-a single defect of conduction and a solitary ventricular extrasystole. Changes in rate were not modified by atropine. It is concluded that manual dilatation of the anus is a safe procedure when carried out under the anaesthetic described and that prior medication with atropine is not necessary. This work supports the view that propanidid protects patients from most abnormalities of heart action which result from intense visceral stimulation.
在丙泮尼地、氧化亚氮和氟烷麻醉并进行心电图监测的情况下，对50例未预先用药的门诊患者实施了肛门手法扩张术。约一半患者在使用丙泮尼地时静脉注射了阿托品。手术引起了心率的多种变化，但在整个实验中仅观察到两个孤立的心律失常复合体——一个单一的传导缺陷和一个孤立的室性早搏。阿托品并未改变心率变化。得出的结论是，在所述麻醉下进行肛门手法扩张术是一种安全的操作，并且无需预先使用阿托品。这项工作支持了丙泮尼地可保护患者免受大多数因强烈内脏刺激导致的心脏活动异常影响的观点。
