Cellular and metabolic tolerance to an opioid narcotic in mouse brain.
作者信息
Goldstein A, Judson B A, Sheehan P
出版信息
Br J Pharmacol. 1973 Jan;47(1):138-40. doi: 10.1111/j.1476-5381.1973.tb08167.x.
Abstract
- Running activity and brain levorphanol concentration were measured in nontolerant and tolerant mice given various doses of (3)H-levorphanol.2. The principal factor responsible for tolerance in the mouse is a loss of sensitivity to the narcotic drug at the cellular level in brain; despite adequate brain concentrations, the pharmacological effects are diminished or absent.3. There is also metabolic tolerance; a given dose establishes a lower brain concentration in tolerant than in non-tolerant animals.4. The two kinds of tolerance are distinguished here and the contribution of each is assessed.
摘要
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Cellular and metabolic tolerance to an opioid narcotic in mouse brain.
Br J Pharmacol. 1973 Jan;47(1):138-40. doi: 10.1111/j.1476-5381.1973.tb08167.x.
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