Siame J L, Sebert J L, Delcambre B
Nouv Presse Med. 1979 May 5;8(20):1675-80.
Otseoporosis is a common and sometimes severe complication of all prolonged corticosteroid therapy. After reviewing the clinical, radiological, histological and biological features, the authors discuss the various physiopathogenic mechanisms: anti-anabolic effect of corticosteroids and decreased bone formation, and hyperparathyroidism secondary to the calcium deficiency induced by corticosteroids (fall in intestinal calcium absorption). Treatment should be preventive, based upon great car in the prescription of corticosteroids (absolute indication, minimal effective dose, alternate administration in certain cases) and upon improved calcium balance (calcium, vitamin D or its derivatives).
骨质疏松是所有长期使用皮质类固醇治疗常见且有时严重的并发症。在回顾临床、放射学、组织学和生物学特征后，作者讨论了各种发病机制：皮质类固醇的抗合成代谢作用及骨形成减少，以及皮质类固醇所致钙缺乏（肠道钙吸收下降）继发的甲状旁腺功能亢进。治疗应具有预防性，基于严格掌握皮质类固醇的处方（绝对适应证、最小有效剂量、某些情况下交替给药）以及改善钙平衡（钙、维生素D或其衍生物）。
