Horwitz C A
Postgrad Med. 1979 Sep;66(3):199-202. doi: 10.1080/00325481.1979.11715258.
A variety of commonly prescribed drugs can produce a positive direct antiglobulin test, but the incidence of actual drug-induced hemolytic anemia is low. Of the four mechanisms which may be responsible, only one involves autoantibody production; the others include drug-RBC interaction of the hapten type, immune complex formation, and direct alteration of the RBC membrane.
多种常用处方药可导致直接抗球蛋白试验呈阳性，但实际由药物引起的溶血性贫血的发生率较低。在可能导致这种情况的四种机制中，只有一种涉及自身抗体的产生；其他机制包括半抗原型的药物与红细胞相互作用、免疫复合物形成以及红细胞膜的直接改变。
