Lane R J, McLelland N J, Martin A M, Mastaglia F L
Postgrad Med J. 1979;55(642):282-5. doi: 10.1136/pgmj.55.642.282.
Two female patients developed a severe, painful proximal myopathy after taking 18--30 g of epsilon-aminocaproic acid daily for 5 weeks. Marked elevations of serum aminotransferases, creatine kinase and aldolase levels were found and the first patient had electromyographic and muscle biopsy changes of an acute monophasic, necrotising myopathy at the height of the illness. Resolution occurred in both cases on stopping the drug and the second patient had no electromyographic or muscle biopsy abnormalities 3 weeks later. Only 2 recognized cases of the condition have been reported previously but a review of the literature revealed several other possible examples.
两名女性患者在连续5周每天服用18 - 30克ε-氨基己酸后出现严重的近端疼痛性肌病。发现血清转氨酶、肌酸激酶和醛缩酶水平显著升高，首例患者在病情高峰期有急性单相坏死性肌病的肌电图和肌肉活检改变。两名患者停药后病情均缓解，第二名患者在3周后肌电图和肌肉活检无异常。此前仅报告过2例确诊病例，但文献回顾发现了其他几个可能的病例。
