Goldstein J L, Hazzard W R, Schrott H G, Bierman E L, Motulsky A G
J Clin Invest. 1973 Jul;52(7):1533-43. doi: 10.1172/JCI107331.
Plasma cholesterol and triglyceride levels were measured after an overnight fast in 500 consecutively studied 3-mo survivors of myocardial infarction. Virtually all patients under 60 yr of age (95% ascertainment) and a randomly chosen group of older survivors admitted to 13 Seattle hospitals during an 11 mo period were included. A comparison of their lipid values with those of 950 controls demonstrated that 31% had hyperlipidemia. These lipid abnormalities were most commonly found in males under 40 yr of age (60% frequency) and in females under 50 yr of age (60% frequency). Elevation in triglyceride levels with (7.8%) or without (15.6%) an associated elevation in cholesterol levels was three times more common in survivors than a high cholesterol level alone (7.6%). These results raise the possibility that hypertriglyceridemia may be as an important a risk factor for coronary atherosclerosis as hypercholesterolemia. The identification of hyperlipidemic survivors of myocardial infarction provided a unique source of probands for family studies designed to disclose the genetic origin of hyperlipidemia in coronary heart disease.
在500名连续接受研究的心肌梗死3个月幸存者中，于禁食过夜后测量了血浆胆固醇和甘油三酯水平。纳入了几乎所有60岁以下的患者（确诊率95%）以及在11个月期间入住13家西雅图医院的一组随机选择的老年幸存者。将他们的血脂值与950名对照者的血脂值进行比较，结果显示31%的患者患有高脂血症。这些血脂异常最常见于40岁以下的男性（发生率60%）和50岁以下的女性（发生率60%）。甘油三酯水平升高伴（7.8%）或不伴（15.6%）胆固醇水平升高的情况在幸存者中比单纯高胆固醇水平（7.6%）更为常见，是其3倍。这些结果增加了一种可能性，即高甘油三酯血症可能与高胆固醇血症一样，是冠状动脉粥样硬化的重要危险因素。识别心肌梗死的高脂血症幸存者为旨在揭示冠心病中高脂血症遗传起源的家族研究提供了独特的先证者来源。
