抗动脉粥样硬化药物吡啶醇胺对心脏、血管及脑生物胺的影响。
The effects of an anti-atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines.
作者信息
Berkowitz B A, Hidaka H, Spector S
出版信息
Br J Pharmacol. 1973 May;48(1):179-81. doi: 10.1111/j.1476-5381.1973.tb08239.x.
Abstract
The anti-atherosclerotic drug pyridinolcarbamate was investigated in the rat for its effects on heart, blood vessel and brain biogenic amines. The drug increased the concentration of noradrenaline in all tissues and of noradrenaline and 5-hydroxytryptamine in the brain. The possibility of a link between biogenic amines and atherosclerotic disease is discussed.
摘要
对抗动脉粥样硬化药物吡啶醇胺在大鼠身上进行了研究，以考察其对心脏、血管和脑生物胺的影响。该药物增加了所有组织中去甲肾上腺素的浓度以及脑中去甲肾上腺素和5-羟色胺的浓度。文中讨论了生物胺与动脉粥样硬化疾病之间存在联系的可能性。
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Pyridinolcarbamate, a bradykinin antagonist in veins. A preliminary report on pharmacologic and clinical observations.吡啶醇氨基甲酸酯，一种静脉中的缓激肽拮抗剂。药理学和临床观察的初步报告。
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