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抗动脉粥样硬化药物吡啶醇胺对心脏、血管及脑生物胺的影响。

The effects of an anti-atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines.

作者信息

Berkowitz B A, Hidaka H, Spector S

出版信息

Br J Pharmacol. 1973 May;48(1):179-81. doi: 10.1111/j.1476-5381.1973.tb08239.x.

DOI:10.1111/j.1476-5381.1973.tb08239.x
PMID:4724191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776097/
Abstract

The anti-atherosclerotic drug pyridinolcarbamate was investigated in the rat for its effects on heart, blood vessel and brain biogenic amines. The drug increased the concentration of noradrenaline in all tissues and of noradrenaline and 5-hydroxytryptamine in the brain. The possibility of a link between biogenic amines and atherosclerotic disease is discussed.

摘要

对抗动脉粥样硬化药物吡啶醇胺在大鼠身上进行了研究，以考察其对心脏、血管和脑生物胺的影响。该药物增加了所有组织中去甲肾上腺素的浓度以及脑中去甲肾上腺素和5-羟色胺的浓度。文中讨论了生物胺与动脉粥样硬化疾病之间存在联系的可能性。

相似文献

1
The effects of an anti-atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines.抗动脉粥样硬化药物吡啶醇胺对心脏、血管及脑生物胺的影响。
Br J Pharmacol. 1973 May;48(1):179-81. doi: 10.1111/j.1476-5381.1973.tb08239.x.
2
The effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain.缺氧对大鼠脑内单胺合成、水平及代谢的影响。
J Neurochem. 1973 Oct;21(4):783-90. doi: 10.1111/j.1471-4159.1973.tb07522.x.
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Effects of the optical isomers of the narcotic antagonist analgesic pentazocine on brain and heart biogenic amines.麻醉拮抗镇痛药喷他佐辛的光学异构体对脑和心脏生物胺的影响。
Eur J Pharmacol. 1974 May;26(2):359-65. doi: 10.1016/0014-2999(74)90247-7.
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Effects of methylmercury on brain biogenic amines in the developing rat pup.甲基汞对发育中大鼠幼崽脑内生物胺的影响。
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J Pharmacol Exp Ther. 1974 Jun;189(3):733-40.
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Arch Int Pharmacodyn Ther. 1974 Feb;207(2):242-53.
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The effect of pronounced hypoglycemia on monoamine metabolism in rat brain.明显低血糖对大鼠脑内单胺代谢的影响。
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Effects of CGP 11305 A, a new reversible and selective inhibitor of MAO A, on biogenic amine levels and metabolism in the rat brain.新型单胺氧化酶A可逆性选择性抑制剂CGP 11305 A对大鼠脑内生物胺水平及代谢的影响
Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(1):20-6. doi: 10.1007/BF00647833.
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Effect of clofibrate on biogenic amine level and turnover.氯贝丁酯对生物胺水平及更新率的影响。
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10
[The effect of small doses of lead acetate on the concentration of biogenic amines].[小剂量醋酸铅对生物胺浓度的影响]
Farmakol Toksikol. 1973 Sep-Oct;36(5):620-4.

本文引用的文献

1
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
2
Edematous arterial reaction by adrenaline and cholesterol and its prevention by MAO Inhibitor observed by electron microscopic technique.通过电子显微镜技术观察肾上腺素和胆固醇引起的水肿性动脉反应及其被单胺氧化酶抑制剂预防的情况。
Jpn Heart J. 1962 Nov;3:581-601. doi: 10.1536/ihj.3.581.
3
Preventive effectiveness of MAO inhibitor and ineffectiveness of prothrombinopenic anticoagulant against increase in plasma thrombin activity by adrenaline, cholesterol, and traumatization.单胺氧化酶抑制剂的预防效果及凝血酶原缺乏性抗凝剂对肾上腺素、胆固醇和创伤引起的血浆凝血酶活性增加的无效性。
Am Heart J. 1962 Jul;64:71-8. doi: 10.1016/0002-8703(62)90094-7.
4
A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine.一种基于犬尿胺消失速率的单胺氧化酶快速分光光度测定法。
J Biol Chem. 1960 Apr;235:1160-3.
5
Pyridinolcarbamate, a bradykinin antagonist in veins. A preliminary report on pharmacologic and clinical observations.吡啶醇氨基甲酸酯，一种静脉中的缓激肽拮抗剂。药理学和临床观察的初步报告。
Am Heart J. 1966 Mar;71(3):297-312. doi: 10.1016/0002-8703(66)90469-8.
6
Amphetamine toxicity in hyperthyroid mice: effects on endogenous catecholamines.甲状腺功能亢进小鼠中的苯丙胺毒性：对内源性儿茶酚胺的影响。
Biochem Pharmacol. 1965 Dec;14(12):1831-7. doi: 10.1016/0006-2952(65)90273-x.
7
Norepinephrine in blood vessels: concentration, binding, uptake and depletion.血管中的去甲肾上腺素：浓度、结合、摄取与耗竭
J Pharmacol Exp Ther. 1971 Apr;177(1):119-26.
8
Disposition of histamine in mammalian blood vessels.组胺在哺乳动物血管中的分布。
J Pharmacol Exp Ther. 1972 Aug;182(2):239-45.
9
Cardiac adrenergic mechanisms in rabbits with experimentally produced coronary atherosclerosis.实验性冠状动脉粥样硬化家兔的心脏肾上腺素能机制
Atherosclerosis. 1972 Jan-Feb;15(1):71-6. doi: 10.1016/0021-9150(72)90038-x.
10
Resistance of noradrenaline in blood vessels to depletion by 6-hydroxydopamine or immunosympathectomy.血管中去甲肾上腺素对6-羟基多巴胺耗竭或免疫交感神经切除术的抵抗作用。
Br J Pharmacol. 1972 Jan;44(1):10-6. doi: 10.1111/j.1476-5381.1972.tb07233.x.