新鲜二尖瓣同种异体移植瓣膜的存活能力。
Viability of fresh mitral homograft valves.
作者信息
al-Janabi N, Ross D N
出版信息
Thorax. 1973 May;28(3):293-4. doi: 10.1136/thx.28.3.293.
The present study was undertaken to measure and compare the viability of the mitral leaflet, chordae, and papillary muscle. The viability of the valves was assessed by autoradiography at regular intervals after sterilization and preservation in antibiotics and nutrient medium. The results showed different rates of decline in viability of the leaflet, muscle, and chordae of the mitral valves. Slightly more than 70% of the leaflet fibroblasts took up thymidine during the first 24 hours of storage. This is compared with 68% of papillary muscle fibroblasts and 40% of chordae fibroblasts. Viability of the chordae decreased rapidly and became pronounced at four weeks. One week is the maximum time for storage of mitral valves if it is desirable to preserve living cells in the chordae.
本研究旨在测量和比较二尖瓣瓣叶、腱索和乳头肌的活力。在灭菌并保存在抗生素和营养培养基中后，通过放射自显影定期评估瓣膜的活力。结果显示二尖瓣瓣叶、肌肉和腱索的活力下降速率不同。在储存的最初24小时内，略多于70%的瓣叶成纤维细胞摄取了胸腺嘧啶核苷。相比之下，乳头肌成纤维细胞为68%，腱索成纤维细胞为40%。腱索的活力迅速下降，在四周时变得明显。如果希望保留腱索中的活细胞，二尖瓣储存的最长时间为一周。
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