前列腺素参与下丘脑对促性腺激素和催乳素释放的调控。
Prostaglandin involvement in hypothalamic control of gonadotropin and prolactin release.
作者信息
Harms P G, Ojeda S R, McCann S M
出版信息
Science. 1973 Aug 24;181(4101):760-1. doi: 10.1126/science.181.4101.760.
PMID:4724933
Abstract
Prostaglandin E(2) (PGE(2)) injected into the third ventricle of ovariectomized rats increased plasma luteinizing hormone dramatically and follicle stimulating hormone slightly. PGE(1) elevated prolactin; PGF(1alpha) or PGF(2alpha) had no effect. PGE(2) or PGE(1) injected directly into the anterior pituitary were ineffective. These results suggest that specific prostaglandins act at the hypothalamus to control pituitary hormone release.
摘要
将前列腺素E(2)（PGE(2)）注入去卵巢大鼠的第三脑室，可显著增加血浆促黄体生成素，轻度增加促卵泡激素。PGE(1)可提高催乳素水平；PGF(1α)或PGF(2α)则无作用。直接注入垂体前叶的PGE(2)或PGE(1)无效。这些结果表明，特定的前列腺素作用于下丘脑以控制垂体激素的释放。
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