Souhami R L
Br J Exp Pathol. 1973 Aug;54(4):380-7.
A method for the production of chronic uraemia in mice is described. Production of humoral antibody has been studied in uraemic mice in response to a primary and secondary challenge with sheep red cells and in response to intraperitoneal and subcutaneous bovine serum albumin (BSA) in complete Freund's adjuvant. In uraemic animals the response to sheep red cells was slightly reduced compared with controls in both the primary and secondary responses. Similarly, the responses to intraperitoneal BSA and subcutaneous BSA in adjuvant was slightly reduced in the uraemic group. The catabolic rate of purified [I] mouse IgG was normal in uraemic animals, indicating that the lower titre of humoral antibody was not due to increased catabolism of immunoglobulin in uraemia.
本文描述了一种在小鼠中产生慢性尿毒症的方法。研究了尿毒症小鼠对绵羊红细胞初次和二次攻击以及对完全弗氏佐剂中腹腔内和皮下注射牛血清白蛋白（BSA）的体液抗体产生情况。在尿毒症动物中，与对照组相比，对绵羊红细胞的初次和二次反应均略有降低。同样，尿毒症组对腹腔内BSA和佐剂中皮下BSA的反应也略有降低。尿毒症动物中纯化的[I]小鼠IgG的分解代谢率正常，这表明体液抗体滴度较低并非由于尿毒症中免疫球蛋白分解代谢增加所致。
