用于白蛋白代谢研究的125I标记人白蛋白商业制剂的经验。

Experience with a commercial preparation of 125I-labelled human albumin for study of albumin metabolism.

作者信息

Ballantyne F C, Fleck A

出版信息

J Clin Pathol. 1973 Jul;26(7):499-502. doi: 10.1136/jcp.26.7.499.

DOI:10.1136/jcp.26.7.499

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC477803/

Abstract

Evaluation of a commercial preparation of (125)I-labelled albumin for use in the study of albumin metabolism is described. In eight subjects with normal albumin metabolism the proportion of the dose of radioiodide excreted was stable throughout a period of 17 days, indicating that there was no excessive denaturation of the iodinated albumin. Characteristics of albumin metabolism-pool sizes, catabolic rate, etc-were in agreement with currently accepted normal values. It is concluded that this preparation of iodinated albumin is suitable for metabolic use.

摘要

本文描述了一种用于白蛋白代谢研究的商业制备的（125）I标记白蛋白的评估。在八名白蛋白代谢正常的受试者中，放射性碘剂量排泄的比例在17天内保持稳定，这表明碘化白蛋白没有过度变性。白蛋白代谢的特征——池大小、分解代谢率等——与目前公认的正常值一致。得出的结论是，这种碘化白蛋白制剂适用于代谢研究。

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本文引用的文献

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EFFICIENT LABELLING OF SERUM PROTEINS WITH I-131 USING CHLORAMINE T.使用氯胺T用I-131对血清蛋白进行高效标记

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4

Studies of I-131-albumin catabolism and distribution in normal young male adults.正常年轻男性成人中碘-131-白蛋白分解代谢与分布的研究。

J Clin Invest. 1962 Jun;41(6):1312-33. doi: 10.1172/JCI104594.

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