胰岛素引发非洲爪蟾卵母细胞的减数分裂成熟。
Meiotic maturation in Xenopus laevis oocytes initiated by insulin.
作者信息
El-Etr M, Schorderet-Slatkine S, Baulieu E E
出版信息
Science. 1979 Sep 28;205(4413):1397-9. doi: 10.1126/science.472755.
PMID:472755
Abstract
Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.
摘要
胰岛素可诱导非洲爪蟾卵母细胞进行减数分裂。这一效应体现了受体介导机制所预期的特异性。它会被乙炔雌二醇增强，乙炔雌二醇是孕酮（引发减数分裂的天然激素）的类固醇拮抗剂。非洲爪蟾卵母细胞可作为研究胰岛素对细胞分裂的作用但却了解甚少的一个模型。
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