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The disposition of propranolol. IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver.

作者信息

Evans G H, Wilkinson G R, Shand D G

出版信息

J Pharmacol Exp Ther. 1973 Sep;186(3):447-54.

PMID:4728328
Abstract
摘要

相似文献

1
The disposition of propranolol. IV. A dominant role for tissue uptake in the dose-dependent extraction of propranolol by the perfused rat liver.
J Pharmacol Exp Ther. 1973 Sep;186(3):447-54.
2
The disposition of propranolol. VII. The effects of saturable hepatic tissue uptake on drug clearance by the perfused rat liver.
Drug Metab Dispos. 1973 Sep-Oct;1(5):679-86.
3
Reduced extraction of I-propranolol by perfused rat liver in the presence of uremic blood.在存在尿毒症血液的情况下，灌注大鼠肝脏对异丙醇的提取减少。
J Pharmacol Exp Ther. 1985 May;233(2):277-84.
4
Hepatic uptake of propranolol.
J Pharmacol Exp Ther. 1978 Jul;206(1):172-80.
5
The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.普萘洛尔的处置。8. 肝血流量对灌注大鼠肝脏消除作用的一般影响
Drug Metab Dispos. 1973 Sep-Oct;1(5):687-90.
6
In vivo study of propranolol and metabolite(s) disposition in rat liver.普萘洛尔及其代谢物在大鼠肝脏中的体内研究。
Drug Metab Dispos. 1981 Nov-Dec;9(6):529-34.
7
The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.普萘洛尔的处置。3. 由于人、猴、狗和大鼠体内的血浆结合作用，半衰期和分布容积降低。
J Pharmacol Exp Ther. 1973 Jul;186(1):114-22.
8
Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding.通过普萘洛尔蛋白结合的扰动来区分离体灌注大鼠肝脏中肝药物消除的静脉平衡模型和窦状隙模型。
J Pharmacol Exp Ther. 1984 May;229(2):522-6.
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Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat.肝硬化时肝脏的清除率。I. 大鼠体外普萘洛尔代谢与其经灌注肝脏摄取之间的关系。
Hepatology. 1993 Feb;17(2):301-6.
10
Effect of inflammation and proadifen on the disposition of antipyrine, lignocaine and propranolol in rat isolated perfused liver.炎症和丙胺太林对大鼠离体灌流肝脏中安替比林、利多卡因和普萘洛尔处置的影响。
J Pharm Pharmacol. 1987 Dec;39(12):997-1002. doi: 10.1111/j.2042-7158.1987.tb03147.x.

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In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.应用钆增强 MRI 对慢性眼高压和降压药物治疗时房水动力学的体内评估。
Invest Ophthalmol Vis Sci. 2014 Apr 24;55(6):3747-57. doi: 10.1167/iovs.14-14263.
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Accumulation kinetics of propranolol in the rat: comparison of Michaelis-Menten-mediated clearance and clearance changes consistent with the "altered enzyme hypothesis".普萘洛尔在大鼠体内的蓄积动力学：米氏介导清除率与符合“酶改变假说”的清除率变化的比较
Pharm Res. 1994 Mar;11(3):420-5. doi: 10.1023/a:1018921306200.
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Time-dependent kinetics of lignocaine in the isolated perfused rat liver.
利多卡因在离体灌注大鼠肝脏中的时间依赖性动力学
J Pharmacokinet Biopharm. 1983 Apr;11(2):165-82. doi: 10.1007/BF01061847.
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Effects of chlorpromazine on the disposition and beta-adrenergic blocking activity of propranolol in the dog.氯丙嗪对狗体内普萘洛尔的处置及β-肾上腺素能阻断活性的影响。
J Pharmacokinet Biopharm. 1984 Jun;12(3):333-49. doi: 10.1007/BF01061724.
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Uptake, subcellular distribution, and transfer processes of imipramine and its metabolites formed in rat liver perfusion systems.丙咪嗪及其在大鼠肝脏灌注系统中形成的代谢产物的摄取、亚细胞分布和转运过程。
Naunyn Schmiedebergs Arch Pharmacol. 1974;284(4):339-52. doi: 10.1007/BF00504703.
6
Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver.维拉帕米对肝硬化大鼠的肝微血管交换及功能有积极影响。
J Clin Invest. 1986 Aug;78(2):448-55. doi: 10.1172/JCI112596.
7
Chronopharmacokinetics of beta-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, sotalol, atenolol) in plasma and tissues after single and multiple dosing in the rat.不同亲脂性β受体阻滞剂（普萘洛尔、美托洛尔、索他洛尔、阿替洛尔）在大鼠单次及多次给药后血浆和组织中的时辰药代动力学。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Jul;330(1):42-9. doi: 10.1007/BF00586708.
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Pharmacokinetic optimisation of therapy with beta-adrenergic blocking agents.β-肾上腺素能阻滞剂治疗的药代动力学优化
Clin Pharmacokinet. 1991 Apr;20(4):311-8. doi: 10.2165/00003088-199120040-00005.
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Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences.药物血浆和组织结合的测定方法。药代动力学后果。
Clin Pharmacokinet. 1992 Dec;23(6):449-68. doi: 10.2165/00003088-199223060-00005.
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Contribution of the liver to overall elimination of propranolol.
J Pharmacokinet Biopharm. 1976 Feb;4(1):17-27. doi: 10.1007/BF01271441.