用甘草次酸治疗的慢性胃溃疡患者胃黏膜的组织学变化。
Histological changes in the gastric mucosa of chronic gastric ulcer patients treated with carbenoxolone.
作者信息
Thomas E, Hall P, Hislop I G
出版信息
Gut. 1973 Jul;14(7):552-4. doi: 10.1136/gut.14.7.552.
Abstract
Serial direct vision gastric mucosal biopsies were obtained in 25 patients with a chronic lesser curve gastric ulcer. Morphological changes were assessed ;blind' in 15 patients who received carbenoxolone and in 10 untreated patients. Chronic gastritis was initially observed ;proximal' and ;distal' to the ulcer in 24 of the 25 patients. The mucosal changes were shown to persist in subsequent biopsies and appeared to be uninfluenced by therapy with carbenoxolone even when the ulcer had healed.
摘要
对25例慢性胃小弯溃疡患者进行了系列直接视野下胃黏膜活检。对15例接受甘草次酸治疗的患者和10例未治疗的患者“盲目”评估形态学变化。在25例患者中的24例中，最初在溃疡的“近端”和“远端”观察到慢性胃炎。黏膜变化在随后的活检中持续存在，即使溃疡已经愈合，似乎也不受甘草次酸治疗的影响。
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