John J A, Blogg C D, Murray F J, Schwetz B A, Gehring P J
Teratology. 1979 Jun;19(3):321-4. doi: 10.1002/tera.1420190307.
These studies evaluated the teratogenic potential of indole-3-acetic acid (IAA), a naturally occurring plant hormone, in CF-1 mice and Sprague-Dawley rats. Mice were given 5, 50, 200, or 500 mg IAA/kg/day by gavage on days 7 through 15 of gestation. Rats were given 50, 200, or 500 mg IAA/kg/day by gavage on days 7 through 15 of gestation. IAA was teratogenic in mice and rats at 500 mg/kg/day; cleft palate was induced in both species at this dose level. In mice, other malformations including exencephaly, ablepharia, dilated cerebral ventricles, and crooked tail were also observed. Mice given 500 mg/kg of IAA gained less than control mice during gestation; no evidence of maternal toxicity was observed in rats. IAA did not cause fetal resorptions in either species and was not teratogenic at dose levels below 500 mg/kg.
这些研究评估了天然存在的植物激素吲哚 - 3 - 乙酸（IAA）对CF - 1小鼠和Sprague - Dawley大鼠的致畸潜力。在妊娠第7至15天，通过灌胃给予小鼠5、50、200或500毫克IAA/千克/天。在妊娠第7至15天，通过灌胃给予大鼠50、200或500毫克IAA/千克/天。IAA在小鼠和大鼠中，剂量为500毫克/千克/天时具有致畸性；在此剂量水平下，两个物种均诱发了腭裂。在小鼠中，还观察到其他畸形，包括无脑畸形、无眼畸形、脑室扩张和尾巴弯曲。给予500毫克/千克IAA的小鼠在妊娠期体重增加少于对照小鼠；在大鼠中未观察到母体毒性的证据。IAA在两个物种中均未引起胎儿吸收，并且在低于500毫克/千克的剂量水平下没有致畸性。
