Beaugrand J, St Laurent J
Br J Pharmacol. 1973 Mar;47(3):609-12. doi: 10.1111/j.1476-5381.1973.tb08192.x.
Rats with electrodes implanted in the posterior lateral hypothalamus and ventromedial tegmentum were trained to self-stimulate. Animals were treated (i.p.) first with alpha-methyl-p-tyrosine (alpha-MPT) and then L-DOPA; their self-stimulation rates and spontaneous behaviour were recorded. alpha-MPT (100 mg/kg) had an immediate and long lasting suppressive effect on self-stimulation, within the first half hour. L-DOPA administration failed to reinstate self-stimulation. Hypoactivity also followed alpha-MPT injections. While the behavioural changes were minimal after L-DOPA 50 mg/kg, a decrease of spontaneous activity and moderate hyper-reactivity were observed following L-DOPA at a dose of 200 mg/kg. Theoretical implications are discussed.
将电极植入下丘脑后侧和中脑腹侧被盖区的大鼠被训练进行自我刺激。首先给动物腹腔注射α-甲基-对-酪氨酸（α-MPT），然后注射左旋多巴（L-DOPA）；记录它们的自我刺激率和自发行为。α-MPT（100毫克/千克）在半小时内对自我刺激有即时且持久的抑制作用。注射L-DOPA未能恢复自我刺激。注射α-MPT后也出现活动减退。虽然注射50毫克/千克L-DOPA后行为变化最小，但注射200毫克/千克L-DOPA后观察到自发活动减少和中度反应过度。文中讨论了相关理论意义。
