Sofia R D, Strasbaugh J E, Banerjee B N
Teratology. 1979 Jun;19(3):361-6. doi: 10.1002/tera.1420190313.
Synthetic delta 9-tetrahydrocannabinol (THC) was dissolved in undiluted propylene glycol and administered in daily subcutaneous doses of 15.0, 30.0 or 60.0 mg/kg to pregnant New Zealand white rabbits on days 7--19 of gestation. Maternal food consumption and weight gain were markedly reduced at all dose levels. Embryotoxicity and embryocidal effects were observed in the form of reduced litter weight and number of viable fetuses, respectively, in offspring from pregnant mothers treated with THC. However, on the basis of extensive external, visceral and skeletal examination of all fetuses it may be concluded that THC is not teratogenic in the New Zealand white strain rabbit following subcutaneous administration of doses as high as 60.0 mg/kg/day during the critical period of organogenesis (days 7--19 of gestation). On the other hand, an oral dose of thalidomide (200.0 mg/kg/day), the positive control used in this study, was both embryocidal and teratogenic.
合成的Δ9-四氢大麻酚（THC）溶解于未稀释的丙二醇中，在妊娠第7至19天，以每日皮下注射剂量15.0、30.0或60.0 mg/kg给予怀孕的新西兰白兔。在所有剂量水平下，母体的食物消耗量和体重增加均显著减少。在用THC处理的怀孕母兔的后代中，分别以出生窝重减轻和存活胎儿数量减少的形式观察到胚胎毒性和胚胎致死作用。然而，基于对所有胎儿进行的广泛的外部、内脏和骨骼检查，可以得出结论，在器官形成的关键时期（妊娠第7至19天），皮下给予高达60.0 mg/kg/天的剂量后，THC在新西兰白兔品系中不具有致畸性。另一方面，本研究中使用的阳性对照沙利度胺口服剂量（200.0 mg/kg/天）具有胚胎致死性和致畸性。
