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大鼠中合成Δ⁹-四氢大麻酚的致畸学评价

Teratologic evaluation of synthetic delta-9-tetrahydrocannabinol in rats.

作者信息

Banerjee B N, Galbreath C, Sofia R D

出版信息

Teratology. 1975 Feb;11(1):99-101. doi: 10.1002/tera.1420110112.

DOI:10.1002/tera.1420110112
PMID:1138409
Abstract

Delta-9-Tetrahydrocannabinol (THC) was dissolved in propylene glycol and 25, 50, or 100 mg/kg administereed dialy sc to pregnant Charles River Sprague-Dawley rats on days 6-15 of gestation (presence of sperm considered day 1). Maternal weight gain was depressed, but a significant decrease in fetal weight occurred only in the 50 mg/kg group. No malformations were noted, only some abnormalities consisting of several instances of rudimentary 14th rib and soft or spongy spinal cords.

摘要

将 Δ-9-四氢大麻酚(THC)溶解于丙二醇中,在妊娠第 6 - 15 天(以发现精子日为第 1 天),每天给怀孕的查尔斯河斯普拉格-道利大鼠腹腔注射 25、50 或 100 mg/kg。母体体重增加受到抑制,但仅在 50 mg/kg 组胎儿体重出现显著下降。未观察到畸形,仅发现一些异常情况,包括几例第 14 肋发育不全以及脊髓柔软或呈海绵状。

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