• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin.

作者信息

Kettner C, Shaw E

出版信息

Thromb Res. 1979;14(6):969-73. doi: 10.1016/0049-3848(79)90014-8.

DOI:10.1016/0049-3848(79)90014-8
PMID:473131
Abstract
摘要

相似文献

1
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin.D-苯丙氨酸-脯氨酸-精氨酸CH2C1——一种凝血酶的选择性亲和标记物。
Thromb Res. 1979;14(6):969-73. doi: 10.1016/0049-3848(79)90014-8.
2
Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein.
Biochemistry. 1978 Oct 31;17(22):4778-84. doi: 10.1021/bi00615a027.
3
Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
J Mol Biol. 1997 Jun 20;269(4):558-69. doi: 10.1006/jmbi.1997.1037.
4
Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and D-Phe-Pro-Arg-Ch2Cl.内源性和外源性凝血过程中因子V的激活。肝素、水蛭素和D-苯丙氨酸-脯氨酸-精氨酸-氯甲基酮的抑制作用。
Biochem J. 1990 Dec 1;272(2):399-406. doi: 10.1042/bj2720399.
5
The solution conformation of (D)Phe-Pro-containing peptides: implications on the activity of Ac-(D)Phe-Pro-boroArg-OH, a potent thrombin inhibitor.
J Med Chem. 1993 Jun 25;36(13):1831-8. doi: 10.1021/jm00065a005.
6
Structure-based understanding of ligand affinity using human thrombin as a model system.以人凝血酶为模型系统基于结构理解配体亲和力。
Biochemistry. 1996 Jul 30;35(30):9690-9. doi: 10.1021/bi952164b.
7
Biotin derivatives of D-Phe-Pro-Arg-CH2Cl for active-site-specific labeling of thrombin and other serine proteinases.用于凝血酶及其他丝氨酸蛋白酶活性位点特异性标记的D-苯丙氨酸-脯氨酸-精氨酸-氯甲基酮的生物素衍生物
Anal Biochem. 2001 Sep 15;296(2):254-61. doi: 10.1006/abio.2001.5302.
8
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H.高活性和高选择性抗凝剂:D-苯丙氨酸-脯氨酸-精氨酸-H,一种易于自发失活的游离三肽醛及其稳定的N-甲基衍生物D-甲基苯丙氨酸-脯氨酸-精氨酸-H。
J Med Chem. 1990 Jun;33(6):1729-35. doi: 10.1021/jm00168a030.
9
Thrombin inhibition by the highly selective 'reversible suicide substrate' N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester.
Protein Pept Lett. 2005 Jul;12(5):433-8. doi: 10.2174/0929866054395301.
10
Active site-directed thrombin inhibitors: alpha-hydroxyacyl-prolyl-arginals, new orally active stable analogues of D-Phe-Pro-Arg-H.
Semin Thromb Hemost. 1996;22(3):243-6. doi: 10.1055/s-2007-999014.

引用本文的文献

1
Small Molecule Protease Inhibitors as Model Peptidomimetics.作为模拟肽的小分子蛋白酶抑制剂
Pharmaceuticals (Basel). 2025 Sep 15;18(9):1377. doi: 10.3390/ph18091377.
2
Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates.白蛋白-凝血酶抑制剂偶联物有效预防动脉血栓形成。
Mol Pharm. 2023 Nov 6;20(11):5476-5485. doi: 10.1021/acs.molpharmaceut.3c00325. Epub 2023 Oct 12.
3
Novel inhibitors and activity-based probes targeting serine proteases.靶向丝氨酸蛋白酶的新型抑制剂及基于活性的探针
Front Chem. 2022 Sep 28;10:1006618. doi: 10.3389/fchem.2022.1006618. eCollection 2022.
4
Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis.用PPACK纳米颗粒抑制凝血酶可恢复实验性动脉粥样硬化中受损的内皮屏障并降低血栓形成风险。
Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):446-55. doi: 10.1161/ATVBAHA.115.306697. Epub 2016 Jan 14.
5
Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement.凝血因子 X 可保护 5 型腺病毒免受天然抗体和补体的攻击。
Nat Med. 2013 Apr;19(4):452-7. doi: 10.1038/nm.3107. Epub 2013 Mar 24.
6
Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies.人凝血酶α在配体识别时的结构和行为:热力学和分子动力学研究。
PLoS One. 2011;6(9):e24735. doi: 10.1371/journal.pone.0024735. Epub 2011 Sep 14.
7
Thrombin-inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis.凝血酶抑制型全氟碳纳米颗粒为急性血栓的治疗和磁共振成像提供了一种新策略。
J Thromb Haemost. 2011 Jul;9(7):1292-300. doi: 10.1111/j.1538-7836.2011.04339.x.
8
Proton bridging in the interactions of thrombin with small inhibitors.凝血酶与小分子抑制剂相互作用中的质子桥连
Biochemistry. 2009 Aug 4;48(30):7296-304. doi: 10.1021/bi900098s.
9
alpha-Thrombin inhibits DNA synthesis in rat hepatocytes but not in hepatoma cells by receptor activation and proteolysis.α-凝血酶通过受体激活和蛋白水解作用抑制大鼠肝细胞中的DNA合成,但不抑制肝癌细胞中的DNA合成。
Mol Cell Biochem. 2007 Oct;304(1-2):189-97. doi: 10.1007/s11010-007-9499-1. Epub 2007 May 22.
10
Expression of functional protease-activated receptor 1 in human prostate cancer cell lines.功能性蛋白酶激活受体1在人前列腺癌细胞系中的表达。
Urol Res. 2003 Jul;31(3):163-8. doi: 10.1007/s00240-003-0309-2. Epub 2003 Mar 25.