抗惊厥药物与运动神经和骨骼肌的棘波传播
Anticonvulsant drugs and spike propagation of motor nerves and skeletal muscle.
作者信息
Hopf H C
出版信息
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):574-80. doi: 10.1136/jnnp.36.4.574.
Abstract
The propagation velocity of evoked muscle spikes was measured and normal values are presented. Carbamazepine, phenobarbitone, diazepam, and bromide-containing drugs were tested for their effect on conduction velocity of motor nerve and skeletal muscle fibres. All these drugs caused a decrease in spike propagation, both of motor nerves and skeletal muscle. After discussion of the probable mode and site of action of these drugs, it was supposed that the underlying events- perhaps changes in permeability of excitable membranes during excitation-are an essential factor in the anticonvulsant action of these drugs.
摘要
测量了诱发肌肉动作电位的传播速度并给出了正常值。对卡马西平、苯巴比妥、地西泮和含溴药物对运动神经和骨骼肌纤维传导速度的影响进行了测试。所有这些药物均导致运动神经和骨骼肌的动作电位传播速度降低。在讨论了这些药物可能的作用方式和作用部位后，推测其潜在机制——或许是兴奋过程中可兴奋膜通透性的改变——是这些药物抗惊厥作用的一个重要因素。
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