Olsen I, Jonsen J
Toxicology. 1979 Feb;12(2):165-72. doi: 10.1016/0300-483x(79)90043-x.
Whole-body autoradiography was used to study nickel uptake and retention in mice throughout gestation. After an intraperitoneal injection of 50 muCi 63NiCl2 into a 16-day-pregnant mouse, nickel appeared rapidly in connective tissues. Prominent sites of radioactivity 72 h after injection included the visceral yolk sac, lung, gastrointestinal tract and kidney. Nickel crossed the placental barriers throughout gestation, i.e. the visceral yolk sac during early gestation, the visceral yolk sac and chorioallantoic placenta during late gestation. A marked uptake of nickel was seen already in the 5- and 6-day embryo. Fetal accumulation of nickel took place up to 16 days gestation. Whereas nickel was distributed throughout the early embryo, distribution became more differentiated with increasing gestation, imitating that in the mother. Penetration of nickel into the mouse conceptus makes possible a similar ability in the human conceptus.
采用全身放射自显影术研究小鼠在整个妊娠期对镍的摄取和潴留情况。给一只怀孕16天的小鼠腹腔注射50微居里的63NiCl2后，镍迅速出现在结缔组织中。注射72小时后，放射性的显著部位包括内脏卵黄囊、肺、胃肠道和肾脏。在整个妊娠期镍都能穿过胎盘屏障，即在妊娠早期穿过内脏卵黄囊，在妊娠晚期穿过内脏卵黄囊和绒毛膜尿囊胎盘。在5天和6天的胚胎中就已观察到镍的明显摄取。胎儿对镍的蓄积一直持续到妊娠16天。镍在早期胚胎中分布于全身，随着妊娠进展分布变得更加分化，类似于母体中的分布。镍进入小鼠孕体表明人类孕体可能也有类似的能力。
