Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine.
作者信息
Baker B R, Ashton W T
出版信息
J Med Chem. 1973 Mar;16(3):209-14. doi: 10.1021/jm00261a009.
PMID:4733101
Abstract
摘要
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1
Irreversible enzyme inhibitors. 197. Water-soluble reversible inhibitors of dihydrofolate reductase with potent antitumor activity derived from 4, 6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine.
J Med Chem. 1973 Mar;16(3):209-14. doi: 10.1021/jm00261a009.
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Irreversible enzyme inhibitors. 173. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihydrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine.不可逆酶抑制剂。173. 源自1-（取代苯基）-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪的二氢叶酸还原酶可逆和不可逆抑制剂对Walker 256腹水的治疗作用
J Med Chem. 1970 Nov;13(6):1130-40. doi: 10.1021/jm00300a026.
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Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group.不可逆酶抑制剂。196. 源自1-(4-苄氧基-3-氯苯基)-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪并带有末端苯磺酸盐基团的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
J Med Chem. 1972 Sep;15(9):945-7. doi: 10.1021/jm00279a017.
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Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride.不可逆酶抑制剂。CLXXVI. 通过醚桥连至末端磺酰氟由4,6-二氨基-1,2-二氢-2,2-二甲基-1-苯基-s-三嗪衍生而来的二氢叶酸还原酶的活性位点导向不可逆抑制剂。
J Med Chem. 1970 Nov;13(6):1149-54. doi: 10.1021/jm00300a029.
6
Irreversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride.不可逆酶抑制剂。CLXXIX。1-（3-氯苯基）-4,6-二氨基-1,2-二氢-2,2-二甲基-s-三嗪与末端磺酰氟通过氧酰胺桥连接的二氢叶酸还原酶的活性位点定向不可逆酶抑制剂。
J Med Chem. 1970 Nov;13(6):1165-70. doi: 10.1021/jm00300a032.
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Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II.不可逆酶抑制剂。CLXXVII。源自4,6 - 二氨基 - 1,2 - 二氢 - 2,2 - 二甲基 - 1 -（苯基烷基苯基）-s-三嗪的二氢叶酸还原酶的活性位点导向不可逆抑制剂。II。
J Med Chem. 1970 Nov;13(6):1154-60. doi: 10.1021/jm00300a030.
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The basis for the disparate sensitivity of L1210 leukemia and Walker 256 carcinoma to a new triazine folate antagonist.
Cancer Res. 1973 Nov;33(11):2972-6.
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Irreversible enzyme inhibitors. CIX. Candidate irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine. 3.不可逆酶抑制剂。CIX。源自4,6-二氨基-1,2-二氢-2,2-二甲基-1-苯基-s-三嗪的二氢叶酸还原酶候选不可逆抑制剂。3。
J Med Chem. 1968 Jan;11(1):26-33. doi: 10.1021/jm00307a005.
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