胆红素酯的合成
The synthesis of esters of bilirubin.
作者信息
Hutchinson D W, Johnson B, Knell A J
出版信息
Biochem J. 1973 Jul;133(3):493-8. doi: 10.1042/bj1330493.
Abstract
1-Alkyl-3-p-tolytriazenes were used to synthesize the methyl, ethyl, isopropyl and benzyl esters of bilirubin. Treatment of a chloroform solution of bilirubin with the triazene at room temperature gave high yields of the corresponding esters. These were identified by n.m.r. and mass spectroscopy together with elemental analysis. N.m.r. studies also suggest that bilirubin dimethyl ester is in the lactam rather than the lactim form.
摘要
1-烷基-3-对甲苯基三氮烯被用于合成胆红素的甲酯、乙酯、异丙酯和苄酯。在室温下，用三氮烯处理胆红素的氯仿溶液可高产率地得到相应的酯。通过核磁共振、质谱以及元素分析对这些酯进行了鉴定。核磁共振研究还表明，胆红素二甲酯呈内酰胺形式而非内酰亚胺形式。
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