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维生素E与新生儿高胆红素血症

Vitamin E in neonatal hyperbilirubinaemia.

作者信息

Abrams B A, Gutteridge J M, Stocks J, Friedman M, Dormandy T L

出版信息

Arch Dis Child. 1973 Sep;48(9):721-4. doi: 10.1136/adc.48.9.721.

DOI:10.1136/adc.48.9.721
PMID:4733642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1648502/
Abstract

The polyunsaturated red cell lipids of newborn infants show a greatly increased susceptibility to autoxidation; and this may be a contributory factor to `physiological' haemolysis. Vitamin E administered by mouth during the first week of life in relatively large doses reduced the susceptibility of red cells to autoxidation, but had no significant effect on the pattern of plasma bilirubin or haemoglobin changes.

摘要

新生儿的多不饱和红细胞脂质对自动氧化的敏感性大大增加;这可能是“生理性”溶血的一个促成因素。在出生后第一周口服相对大剂量的维生素E可降低红细胞对自动氧化的敏感性,但对血浆胆红素或血红蛋白变化模式没有显著影响。

相似文献

1
Vitamin E in neonatal hyperbilirubinaemia.维生素E与新生儿高胆红素血症
Arch Dis Child. 1973 Sep;48(9):721-4. doi: 10.1136/adc.48.9.721.
2
Ethanol in prevention of hyperbilirubinaemia in the newborn. A controlled trial.乙醇预防新生儿高胆红素血症。一项对照试验。
Lancet. 1969 Dec 13;2(7633):1265-7. doi: 10.1016/s0140-6736(69)90805-8.
3
Prophylaxis of neonatal hyperbilirubinemia with phenobarbital.苯巴比妥预防新生儿高胆红素血症
Obstet Gynecol. 1972 Jul;40(1):85-90.
4
The effect of vitamin E on red cell hemolysis and bilirubinemia.
Ann N Y Acad Sci. 1982;393:315-22. doi: 10.1111/j.1749-6632.1982.tb31271.x.
5
Vitamin E and hyperbilirubinemia in Chinese newborn infants.中国新生儿的维生素E与高胆红素血症
Taiwan Yi Xue Hui Za Zhi. 1981 Feb;80(2):149-57.
6
Phenobarbitone prophylaxis for neonatal hyperbilirubinemia.苯巴比妥预防新生儿高胆红素血症。
Pediatrics. 1971 Sep;48(3):372-6.
7
Carboxyhemoglobin concentration as an index of bilirubin production in neonates with birth weights less than 1,500 grams: a randomized double-blind comparison of supplemental oral vitamin E and placebo.以碳氧血红蛋白浓度作为出生体重低于1500克新生儿胆红素生成指标:补充口服维生素E与安慰剂的随机双盲对照研究
J Pediatr Gastroenterol Nutr. 1987 Sep-Oct;6(5):748-51. doi: 10.1097/00005176-198709000-00015.
8
Nursery illumination as a factor in neonatal hyperbilirubinemia.
Pediatrics. 1969 Aug;44(2):155-7.
9
Vitamin E and neonatal bilirubinemia.维生素E与新生儿高胆红素血症
Pediatrics. 1979 Sep;64(3):321-3.
10
Plasma concentrations of phenobarbital in the neonate during prophylaxis for neonatal hyperbilirubinemia.
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引用本文的文献

1
Altered trace elements, antioxidant vitamin C, and malondialdehyde levels are associated with the pathophysiology and development of pre-hepatic jaundice: A case-control study.微量元素、抗氧化维生素C及丙二醛水平的改变与肝前性黄疸的病理生理学及发展相关:一项病例对照研究。
SAGE Open Med. 2024 Oct 17;12:20503121241291977. doi: 10.1177/20503121241291977. eCollection 2024.
2
Physiological and therapeutic role of vitamin E in humans: an update.维生素E在人体中的生理及治疗作用:最新进展
Indian J Pediatr. 1984 Nov-Dec;51(413):715-24. doi: 10.1007/BF02776390.

本文引用的文献

1
Hemolysis in hydrogen peroxide of erythrocytes of premature infants; effect of alpha-tocopherol.过氧化氢对早产儿红细胞的溶血作用;α-生育酚的影响。
Proc Soc Exp Biol Med. 1952 Mar;79(3):446-50. doi: 10.3181/00379727-79-19408.
2
HUMAN FETL ERYTHROCYTE AND PLASMA LIPIDS.人类胎儿红细胞和血浆脂质。 不过你原文中“FETL”应该是“FETAL”的错误拼写。
J Clin Invest. 1965 Jun;44(6):989-98. doi: 10.1172/JCI105216.
3
Studies of tocopherol deficiency in infants and children. I. Hemolysis of erythrocytes in hydrogen peroxide.婴幼儿维生素E缺乏症的研究。I. 红细胞在过氧化氢中的溶血作用。
AMA Am J Dis Child. 1955 Dec;90(6):669-81. doi: 10.1001/archpedi.1955.04030010671002.
4
Relation between serum tocopherol and hemolysis in hydrogen peroxide of erythrocytes in premature infants.
Pediatrics. 1954 Apr;13(4):346-51.
5
Availability of vitamin E in the newborn infant.新生儿体内维生素E的可利用性。
Proc Soc Exp Biol Med. 1952 Nov;81(2):536-8. doi: 10.3181/00379727-81-19931.
6
Vitamin E deficiency: a previously unrecognized cause of hemolytic anemia in the premature infant.维生素E缺乏:早产儿溶血性贫血的一个先前未被认识的病因。
J Pediatr. 1967 Feb;70(2):211-20. doi: 10.1016/s0022-3476(67)80416-5.
7
Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells.人类红细胞中磷脂、磷脂脂肪酸及醛类的组成
J Lipid Res. 1967 Nov;8(6):667-75.
8
Syndrome in premature infants associated with low plasma vitamin E levels and high polyunsaturated fatty acid diet.
Am J Clin Nutr. 1966 Sep;19(3):147-57. doi: 10.1093/ajcn/19.3.147.
9
Rapid determination of tocopherol in marco- and microquantities of plasma. Results obtained in various nutrition and metabolic studies.
Am J Clin Nutr. 1966 Aug;19(2):137-45. doi: 10.1093/ajcn/19.2.137.
10
Edema and hemolytic anemia in premature infants. A vitamin E deficiency syndrome.
N Engl J Med. 1968 Nov 28;279(22):1185-90. doi: 10.1056/NEJM196811282792202.