组织相容性（HL-A）抗体与补体在连续培养中与同步化人淋巴细胞的相互作用。
Interaction of histocompatibility (HL-A) antibodies and complement with synchronized human lymphoid cells in continuous culture.
作者信息
Ferrone S, Cooper N R, Pellegrino M A, Reisfeld R A
出版信息
J Exp Med. 1973 Jan 1;137(1):55-68. doi: 10.1084/jem.137.1.55.
Abstract
The interaction of histocompatibility (HL-A) antibodies and complement with synchronized human lymphoid cells in continuous culture has been investigated. The sensitivity of cultured lymphoid cells to HL-A antibody-mediated lysis in the cytotoxic test, the extent of activation of the complement system, the degree to which labeled complement components are bound, and the ability of these cells to absorb HL-A alloantibodies do not vary significantly during the cell growth cycle. The constancy of histocompatibility antigen expression throughout the growth cycle of cultured cells suggests that these cell surface markers are an essential part of membrane cytoarchitecture and could well play a critical role in determining the normal function of the cell membrane.
摘要
已对组织相容性（HL - A）抗体和补体与连续培养中的同步化人淋巴细胞的相互作用进行了研究。在细胞毒性试验中，培养的淋巴细胞对HL - A抗体介导的细胞溶解的敏感性、补体系统的激活程度、标记补体成分的结合程度以及这些细胞吸收HL - A同种抗体的能力在细胞生长周期中并无显著变化。培养细胞整个生长周期中组织相容性抗原表达的稳定性表明，这些细胞表面标志物是细胞膜细胞结构的重要组成部分，很可能在决定细胞膜的正常功能中发挥关键作用。
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2
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3
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Ann N Y Acad Sci. 1956 Mar 14;63(5):706-10. doi: 10.1111/j.1749-6632.1956.tb50887.x.
4
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7
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