Raccuglia G, Lansing A
Clin Exp Immunol. 1973 May;14(1):1-18.
The results of spleen transplantation from a healthy individual to his leukaemic identical twin are reported. The rationale for the procedure and its significance in relation to present hypotheses of tumour growth and spread are reviewed. Although lymphocytes of both the donor and recipient showed specific immune capacity to destroy tumour cells , there was evidence for partial inhibition of the immunological effector process that destroys the tumour cells in the diminished lymphocyte phytoagglutinin stimulation, hypoglobulinaemia, and marked deficiency of IgA in the leukaemic twin. These abnormalities and the final relapse in spite of transplantation of the spleen as a source of immunocompetent cells could also be considered the result of growth potential in the tumour, capable of overriding any immunological control.
报告了从健康个体向其患白血病的同卵双胞胎进行脾移植的结果。回顾了该手术的基本原理及其与当前肿瘤生长和扩散假说相关的意义。尽管供体和受体的淋巴细胞均显示出破坏肿瘤细胞的特异性免疫能力，但有证据表明，在白血病双胞胎中，淋巴细胞植物血凝素刺激减弱、低球蛋白血症和IgA明显缺乏，导致破坏肿瘤细胞的免疫效应过程受到部分抑制。尽管移植了作为免疫活性细胞来源的脾脏，但这些异常情况以及最终的复发也可被视为肿瘤生长潜能的结果，这种潜能能够超越任何免疫控制。
