Adhami H
Z Mikrosk Anat Forsch. 1979;93(1):21-32.
The prenatal cortex development after the application of 6-Mercaptopurine (6-MP) was studied in the rat embryo. 24 h after application of a single dose of 6-MP on day 12, 13, 14 or 15 of gestation first cell lesions occured in the form of necroses. 48 h after injection of the drug these necroses were most pronounced. Their extent and distribution pattern was, however, dependent on the developmental stage. In the early developmental phase, on days 12 and 13, massive necroses could be observed in the intermediate zone. At later stages of development (drug application on day 14 or 15) damaged cells could occasionally also be found scattered over the whole ventricular wall. The late toxic response to 6-MP treatment suggests that, after incorporation of metabolites of the agent into DNA during the S-phase, at least one additional S-phase is completed before the disturbance created in a cell is sufficient to cause necrosis. The necrosis may be a result of an action of 6-MP directly on DNA or via an affect on transcription. The different extent of the lesion during the various developmental phases suggests different growth dynamics of the cortex.
在大鼠胚胎中研究了应用6-巯基嘌呤（6-MP）后产前皮质的发育情况。在妊娠第12、13、14或15天单次应用6-MP后24小时，首次出现以坏死形式存在的细胞损伤。注射药物后48小时，这些坏死最为明显。然而，其范围和分布模式取决于发育阶段。在发育早期，即第12天和第13天，在中间区可观察到大量坏死。在发育后期（第14天或第15天应用药物），偶尔也可发现受损细胞散在于整个室壁。对6-MP治疗的晚期毒性反应表明，在S期该药物的代谢产物掺入DNA后，在细胞内产生的干扰足以导致坏死之前，至少还完成了一个额外的S期。坏死可能是6-MP直接作用于DNA或通过影响转录的结果。不同发育阶段损伤程度的差异表明皮质具有不同的生长动力学。
