Descotes J, Lievre M, Ollagnier M, Faucon G, Evreux J C
Acta Pharmacol Toxicol (Copenh). 1979 May;44(5):370-6. doi: 10.1111/j.1600-0773.1979.tb02347.x.
The effect of thioridazine on sinusal automaticity, myocardial excitability and auriculoventricular conduction have been studied in dogs by measuring the spontaneous heart rate, the effective refractory period of the atrial contractile tissue, the time of auriculonodal and infrahisian conduction. Chloralose anaesthetized dogs were administered 10 mg/kg thioridazine hydrochloride via intravenous route. While sinusal automaticity was not altered, conduction times were prolonged in the suprahisian and mainly the infrahisian part and the atrial refractory period increased. These effects are related to quinidine-like properties and consistent with cardiotoxic effects previously reported in clinical practice.
通过测量自发心率、心房收缩组织的有效不应期、房结和希氏束下传导时间，研究了硫利达嗪对犬窦性自律性、心肌兴奋性和房室传导的影响。用氯醛糖麻醉犬，经静脉途径给予10mg/kg盐酸硫利达嗪。虽然窦性自律性未改变，但希氏束上尤其是希氏束下的传导时间延长，心房不应期增加。这些作用与奎尼丁样特性有关，并且与先前临床实践中报道的心脏毒性作用一致。
