Putnam F W, Florent G, Paul C, Shinoda T, Shimizu A
Science. 1973 Oct 19;182(4109):287-91. doi: 10.1126/science.182.4109.287.
The amino acid sequence of the micro, chain of a human IgM immunoglobulin, including the location of all disulfide bridges and oligosaccharides, has been determined. The homology of the constant regions of immunoglobulin micro, gamma, alpha, and epsilon heavy chains reveals evolutionary relationships and suggests that two genes code for each heavy chain.
已确定人IgM免疫球蛋白μ链的氨基酸序列,包括所有二硫键和寡糖的位置。免疫球蛋白μ、γ、α和ε重链恒定区的同源性揭示了进化关系,并表明每条重链由两个基因编码。